Immediate danger or someone is unresponsive?Call 112

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Harm reduction saves lives

Practical, non-judgemental information about drugs, risks, first response, and where to get help in Iceland.

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Substance library

Common substances and drug classes

This list covers substances people may encounter, but it is not exhaustive. New and altered substances continue to appear.

Inside each entryOpen an entry to see effects, risks, safer-use advice, dose-reference limitations, emergency steps and sources.

Opioids

7

Urgent warning

Call 112 if

Very slow, irregular, or absent breathing; blue or grey lips; very small pupils; or no response.

Call 112

Main risks

What matters most

  • Overdose and respiratory arrest
  • Unconsciousness and choking
  • Dependence and rapidly changing tolerance

Mixing

Combining with other substances

Do not combine with benzodiazepines, GHB/GBL, alcohol, or other depressants. This greatly increases the risk of respiratory arrest.

Effects and risk reduction

Effects and safer use

Common effects

Relaxation, pain relief, drowsiness, and euphoria. The strength of illicit substances can be highly unpredictable.

If you choose to use
  • Do not use alone
  • Get free naloxone (from Frú Ragnheiður, Ylja, primary healthcare, or the police) and tell others where it is
  • Assume your tolerance is lower after a break

Chemical structure

This name covers multiple molecules or unknown contents. A single structural formula cannot represent it; choose a specific substance to see its structure.

More information

Experience, timeline, emergency steps and sources

What the experience may feel like

The experience can include warmth, pain relief, relaxation, drowsiness, and a sense of distance from the surroundings. As the effect becomes stronger, speech, balance, and consciousness become impaired, and breathing can slow without the person realising the danger.

Duration by route

No single duration applies to this group or unknown contents. Choose a specific substance for route-specific information where available.

Source: PsychonautWiki · Data retrieved

Dose information

There is no single dose figure for opioids. Fentanyl, heroin, methadone, buprenorphine, and other opioids differ greatly in potency and duration. Numerical information is shown only inside a separately reviewed entry for the specific substance.

If the experience becomes an emergency

Emergency steps for Opioids: general overview
  1. Call 112 immediately if a person is unresponsive or is breathing slowly, irregularly, or not at all.
  2. If naloxone nasal spray (for example Nyxoid) is available, give one spray into one nostril as soon as opioid use is suspected.
  3. Wait 2–3 minutes. If there is no improvement or symptoms return, use a new device to give another dose into the other nostril.
  4. Provide rescue breathing or CPR as directed by 112 while waiting for the naloxone to work.
  5. If the person is breathing normally, place them in the recovery position, keep them warm, and stay with them until help arrives.
  6. Do not stop monitoring the person even if symptoms improve: naloxone can wear off before the overdose does, so symptoms can return. The person always needs professional assessment after naloxone is given.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Very slow, shallow, irregular, or absent breathing; blue or grey lips; very small pupils; snoring-like sounds; or no response.

Call 112

Main risks

What matters most

  • Overdose and respiratory arrest
  • Unconsciousness, vomiting, and aspiration
  • Dependence, constipation, and withdrawal

Mixing

Combining with other substances

Benzodiazepines, alcohol, gabapentinoids, GHB/GBL, and other depressants increase the risk of unconsciousness, respiratory arrest, and death.

Effects and risk reduction

Effects and safer use

Common effects

Pain relief, relaxation, drowsiness, euphoria, and nausea. Effects become less predictable after a break or with other depressants.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you
  • Do not use alone and keep naloxone available
  • Assume your tolerance is lower after a break and seek medical advice before stopping regular use

Chemistry

Chemical structure

PubChem
2D structural formula: Morphine. (4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
MorphineC17H19NO3
PubChem · CID 5288826
Exact molecular identity

(4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Morphine is an opioid that can cause pain relief, warmth, relaxation, and drowsiness. As the effects become stronger, consciousness and breathing are impaired; a person may breathe slowly or stop breathing without realising the danger.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table republishes only the existing community-reported ranges for oral and intravenous morphine. It is not medical dosing advice, and the routes are not interchangeable. Tolerance, a break from use, formulation, health, and other depressants can change the risk substantially.

Morphine by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 22 July 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. Amounts apply only to morphine and the route shown in the same row. They are not medical dosing advice and must not be converted between routes.

Morphine

RouteOral

Threshold
<10 mg
Light
10–15 mg
Common
15–20 mg
Strong
20–30 mg
Heavy
≥30 mg

Note: Oral bioavailability varies.

Morphine

RouteIntravenous

Threshold
<3.33 mg
Light
3.33–5 mg
Common
5–7.5 mg
Strong
7.5–10 mg
Heavy
≥10 mg

Note: Intravenous use acts faster and has a much narrower margin for error than oral use.

If the experience becomes an emergency

Emergency steps for Morphine
  1. Call 112 immediately if a person is unresponsive or is breathing slowly, irregularly, or not at all.
  2. If naloxone nasal spray (for example Nyxoid) is available, give one spray into one nostril as soon as opioid use is suspected.
  3. Wait 2–3 minutes. If there is no improvement or symptoms return, use a new device to give another dose into the other nostril.
  4. Provide rescue breathing or CPR as directed by 112 while waiting for the naloxone to work.
  5. If the person is breathing normally, place them in the recovery position, keep them warm, and stay with them until help arrives.
  6. Do not stop monitoring the person even if symptoms improve: naloxone can wear off before the overdose does, so symptoms can return. The person always needs professional assessment after naloxone is given.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Very slow, shallow, irregular, or absent breathing; blue or grey lips; very small pupils; snoring-like sounds; or no response.

Call 112

Main risks

What matters most

  • Overdose and respiratory arrest
  • Potentially fatal rapid release if an extended-release tablet is crushed, chewed, or dissolved
  • Counterfeit tablets with unknown or different contents

Mixing

Combining with other substances

Benzodiazepines, alcohol, gabapentinoids, GHB/GBL, and other depressants increase the risk of profound sedation, respiratory arrest, and death.

Effects and risk reduction

Effects and safer use

Common effects

Pain relief, relaxation, drowsiness, euphoria, nausea, and slower breathing. Extended-release medicines can have prolonged effects.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you, and never alter an extended-release tablet
  • A tablet's appearance, imprint, or name does not confirm its contents
  • Do not use alone and keep naloxone available

Chemistry

Chemical structure

PubChem
2D structural formula: Oxycodone. (4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
OxycodoneC18H21NO4
PubChem · CID 5284603
Exact molecular identity

(4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Oxycodone is an opioid that can cause pain relief, relaxation, euphoria, and drowsiness. Excessive effects can lead to profound drowsiness, unresponsiveness, and life-threatening respiratory depression.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table shows only the existing community-reported ranges for oxycodone and the listed routes. It is not a prescription and does not automatically apply to OxyContin or any other specific formulation. A tablet marked OxyContin confirms neither its contents nor strength outside a secure medicine supply chain.

Oxycodone by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 22 July 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. Amounts apply only to oxycodone and the route shown in the same row. They are not medical dosing advice and must not be used to alter an extended-release product.

Oxycodone

RouteSmoked

Threshold
1 mg
Light
1.5–8 mg
Common
8–20 mg
Strong
20–35 mg
Heavy
≥30 mg

Note: The “Strong” and “Heavy” ranges overlap in the source; this underlines that the table does not show safety limits.

Oxycodone

RouteOral

Threshold
1 mg
Light
2.5–10 mg
Common
10–25 mg
Strong
25–40 mg
Heavy
≥40 mg

Note: Counterfeit tablets may contain nitazenes or fentanyl.

Oxycodone

RouteIntranasal

Threshold
1 mg
Light
2.5–7.5 mg
Common
7.5–15 mg
Strong
15–25 mg
Heavy
≥25 mg

Note: The potency and adulteration of powders are often unknown.

Oxycodone

RouteIntravenous

Threshold
1 mg
Light
2.5–5 mg
Common
7.5–10 mg
Strong
12.5–15 mg
Heavy
≥15 mg

Note: There are gaps between categories in the source; do not fill them in by inference.

If the experience becomes an emergency

Emergency steps for Oxycodone
  1. Call 112 immediately if a person is unresponsive or is breathing slowly, irregularly, or not at all.
  2. If naloxone nasal spray (for example Nyxoid) is available, give one spray into one nostril as soon as opioid use is suspected.
  3. Wait 2–3 minutes. If there is no improvement or symptoms return, use a new device to give another dose into the other nostril.
  4. Provide rescue breathing or CPR as directed by 112 while waiting for the naloxone to work.
  5. If the person is breathing normally, place them in the recovery position, keep them warm, and stay with them until help arrives.
  6. Do not stop monitoring the person even if symptoms improve: naloxone can wear off before the overdose does, so symptoms can return. The person always needs professional assessment after naloxone is given.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Very slow, shallow, or irregular breathing; blue or grey lips; small pupils; snoring-like sounds; or no response.

Call 112

Main risks

What matters most

  • Respiratory depression, unconsciousness, and overdose
  • Unpredictable conversion into morphine due to CYP2D6
  • Dependence and withdrawal

Mixing

Combining with other substances

Alcohol, benzodiazepines, sleeping medicines, gabapentinoids, other opioids, and other depressants increase the risk of profound sedation, respiratory depression, and death.

Effects and risk reduction

Effects and safer use

Common effects

Pain relief, drowsiness, relaxation, nausea, and constipation. Stronger effects can slow breathing and impair consciousness.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you
  • Check whether the medicine also contains paracetamol and do not take other paracetamol medicines with it
  • Do not use alone and keep naloxone available

Chemistry

Chemical structure

PubChem
2D structural formula: Codeine. (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol
CodeineC18H21NO3
PubChem · CID 5284371
Exact molecular identity

(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-ol

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Codeine is an opioid that can cause pain relief, drowsiness, relaxation, nausea, and constipation. The body converts some codeine into morphine, so its effects may be weak in one person but dangerously strong in another.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table republishes PsychonautWiki’s user-reported ranges for oral codeine. It is not medical dosing advice or a safety limit. Conversion of codeine into morphine varies between people, and Parkódín and Parkódín forte also contain paracetamol, which can cause severe liver injury in overdose.

Codeine by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 10 September 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. The amounts apply only to oral codeine. Conversion to morphine, formulation, and other active ingredients can change the risk substantially.

Codeine

RouteOral

Threshold
30 mg
Light
50–100 mg
Common
100–150 mg
Strong
150–200 mg
Heavy
≥200 mg

Note: Conversion to morphine varies greatly between people. Combination medicines may also contain paracetamol, which can cause severe liver injury.

If the experience becomes an emergency

Emergency steps for Codeine
  1. Call 112 immediately if a person is unresponsive or is breathing slowly, irregularly, or not at all.
  2. If naloxone nasal spray (for example Nyxoid) is available, give one spray into one nostril as soon as opioid use is suspected.
  3. Wait 2–3 minutes. If there is no improvement or symptoms return, use a new device to give another dose into the other nostril.
  4. Provide rescue breathing or CPR as directed by 112 while waiting for the naloxone to work.
  5. If the person is breathing normally, place them in the recovery position, keep them warm, and stay with them until help arrives.
  6. Do not stop monitoring the person even if symptoms improve: naloxone can wear off before the overdose does, so symptoms can return. The person always needs professional assessment after naloxone is given.
  7. If Parkódín or another combination medicine may be involved, urgent assessment is also needed because of paracetamol. Call the Poison Information Centre on 543 2222 immediately, or 112 in an emergency, even if early symptoms seem mild.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Slow or irregular breathing, no response, a seizure, or a high temperature with agitation, confusion, tremor, or muscle rigidity.

Call 112

Main risks

What matters most

  • Respiratory depression, unconsciousness, and overdose
  • Seizures
  • Serotonin syndrome, dependence, and withdrawal

Mixing

Combining with other substances

Alcohol, benzodiazepines, and other depressants increase breathing risks. SSRIs, SNRIs, MAO inhibitors, and other serotonergic substances can increase the risk of serotonin syndrome and seizures.

Effects and risk reduction

Effects and safer use

Common effects

Pain relief, sedating effects, drowsiness, dizziness, nausea, sweating, and constipation. Stronger effects can impair consciousness and breathing.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you
  • Do not use alone and keep naloxone available
  • Seek medical advice before stopping regular use

Chemistry

Chemical structure

PubChem
2D structural formula: Tramadol. cis-(1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol
TramadolC16H25NO2
PubChem · CID 33741
Exact molecular identity

cis-(1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Tramadol is an opioid pain medicine that can cause pain relief, drowsiness, dizziness, nausea, and sweating. It also affects noradrenaline and serotonin, so it can cause seizures or serotonin syndrome as well as typical opioid poisoning.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table republishes PsychonautWiki’s user-reported ranges for oral tramadol. It is not medical dosing advice or a safety limit. Seizures have occurred during ordinary medical use, and the risk rises with larger amounts, other medicines that lower the seizure threshold, and serotonergic substances.

Tramadol by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 10 September 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. The amounts apply only to oral tramadol. Seizures and serotonin syndrome can occur within or below the published ranges.

Tramadol

RouteOral

Threshold
25 mg
Light
25–100 mg
Common
100–250 mg
Strong
250–300 mg
Heavy
≥300 mg

Note: Seizures and serotonin syndrome can occur; risk increases with substances including MDMA, stimulants, and many antidepressants.

If the experience becomes an emergency

Emergency steps for Tramadol
  1. Call 112 immediately for slow or abnormal breathing, no response, a seizure, or a high temperature with agitation, confusion, tremor, or muscle rigidity.
  2. If breathing is not normal, provide rescue breathing or CPR as directed by 112.
  3. Give naloxone if opioid-related respiratory depression is suspected and naloxone is available. It may reverse respiratory depression but does not treat seizures or serotonin syndrome.
  4. If the person is breathing normally, place them in the recovery position, stay with them, and monitor them continuously until help arrives.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Very slow or absent breathing; blue or grey lips; rigidity; snoring-like sounds; or no response.

Call 112

Main risks

What matters most

  • Very rapid respiratory arrest
  • A microgram error or the wrong formulation
  • Counterfeit medicines or powders with unknown contents

Mixing

Combining with other substances

Alcohol, benzodiazepines, GHB/GBL, gabapentinoids, and other depressants can cause fatal respiratory depression.

Effects and risk reduction

Effects and safer use

Common effects

Powerful pain relief, drowsiness, and slower breathing. An overdose can develop quickly and without a clear warning.

If you choose to use
  • Only take pharmacy-supplied fentanyl prescribed to you
  • Do not use alone and keep naloxone available
  • The appearance of a tablet, powder, or patch does not confirm its contents outside a secure medicine supply chain

Chemistry

Chemical structure

PubChem
2D structural formula: Fentanyl. N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
FentanylC22H28N2O
PubChem · CID 3345
Exact molecular identity

N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, emergency steps and sources

What the experience may feel like

Fentanyl can cause powerful pain relief and drowsiness, but respiratory depression can develop very quickly. A microgram error or the wrong formulation can be fatal.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose information

No numerical community dose table is published; the wrong unit, an unknown concentration, or uneven distribution can cause death.

If the experience becomes an emergency

Emergency steps for Fentanyl
  1. Call 112 immediately if a person is unresponsive or is breathing slowly, irregularly, or not at all.
  2. If naloxone nasal spray (for example Nyxoid) is available, give one spray into one nostril as soon as opioid use is suspected.
  3. Wait 2–3 minutes. If there is no improvement or symptoms return, use a new device to give another dose into the other nostril.
  4. Provide rescue breathing or CPR as directed by 112 while waiting for the naloxone to work.
  5. If the person is breathing normally, place them in the recovery position, keep them warm, and stay with them until help arrives.
  6. Do not stop monitoring the person even if symptoms improve: naloxone can wear off before the overdose does, so symptoms can return. The person always needs professional assessment after naloxone is given.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Very slow or absent breathing, blue or grey lips, small pupils, snoring-like sounds, or no response.

Call 112

Main risks

What matters most

  • Very rapid overdose and respiratory arrest
  • Mislabelled tablets or mixtures
  • Repeated doses of naloxone may be needed

Mixing

Combining with other substances

Do not combine with alcohol, benzodiazepines, GHB/GBL, pregabalin, or other depressants.

Effects and risk reduction

Effects and safer use

Common effects

Relaxation, pain relief, drowsiness, and euphoria. The actual contents and strength may be unknown.

If you choose to use
  • Assume an unknown powder or tablet may contain a potent opioid
  • Do not use alone and keep naloxone available
  • Start CPR as instructed by 112 if breathing is not normal

Chemical structure

This name covers multiple molecules or unknown contents. A single structural formula cannot represent it; choose a specific substance to see its structure.

More information

Experience, timeline, emergency steps and sources

What the experience may feel like

Nitazenes can resemble other opioids, causing relaxation, pain relief, drowsiness, and euphoria. Breathing and consciousness can, however, become impaired very quickly, especially when a nitazene is hidden in a product sold as another substance.

Duration by route

No single duration applies to this group or unknown contents. Choose a specific substance for route-specific information where available.

Source: PsychonautWiki · Data retrieved

Dose information

No dose amount is published. Nitazenes vary in potency, can be much more potent than many other opioids, and may be distributed unevenly through powder or counterfeit tablets.

If the experience becomes an emergency

Emergency steps for Nitazene opioids
  1. Call 112 immediately if a person is unresponsive or is breathing slowly, irregularly, or not at all.
  2. If naloxone nasal spray (for example Nyxoid) is available, give one spray into one nostril as soon as opioid use is suspected.
  3. Wait 2–3 minutes. If there is no improvement or symptoms return, use a new device to give another dose into the other nostril.
  4. Provide rescue breathing or CPR as directed by 112 while waiting for the naloxone to work.
  5. If the person is breathing normally, place them in the recovery position, keep them warm, and stay with them until help arrives.
  6. Do not stop monitoring the person even if symptoms improve: naloxone can wear off before the overdose does, so symptoms can return. The person always needs professional assessment after naloxone is given.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Sedatives and depressants

16

Urgent warning

Call 112 if

Difficult to wake, very slow breathing, confusion, repeated vomiting, or unconsciousness.

Call 112

Main risks

What matters most

  • Memory loss and accidents
  • Impaired consciousness
  • Severe withdrawal after regular use

Mixing

Combining with other substances

Especially dangerous with opioids, alcohol, GHB/GBL, and other depressant medicines.

Effects and risk reduction

Effects and safer use

Common effects

Relaxation, reduced anxiety, drowsiness, and slower reactions.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you
  • Do not drive or go near water or heights
  • Do not stop suddenly after regular use. Seek medical advice

Chemical structure

This name covers multiple molecules or unknown contents. A single structural formula cannot represent it; choose a specific substance to see its structure.

More information

Experience, timeline, emergency steps and sources

What the experience may feel like

Common effects include reduced anxiety, relaxation, drowsiness, and emotional detachment. Memory loss, impaired judgement, and unsteadiness can increase quickly, and a person may appear awake but remember very little later.

Duration by route

No single duration applies to this group or unknown contents. Choose a specific substance for route-specific information where available.

Source: PsychonautWiki · Data retrieved

Dose information

There is no single dose figure for benzodiazepines. Milligrams of one medicine are not equivalent to milligrams of another, and numerical information is shown only inside a separately reviewed entry for the specific medicine.

If the experience becomes an emergency

Emergency steps for Benzodiazepines: general overview
  1. Stop all further use and do not give food, drink, or any other substances.
  2. Check responsiveness and breathing. Call 112 if the person is difficult to wake, is breathing abnormally, vomits while their consciousness is impaired, or has a seizure.
  3. If the person is breathing normally, place them in the recovery position and monitor their breathing continuously.
  4. Give naloxone only when opioid use is suspected. Naloxone does not reverse alcohol, GHB, or benzodiazepines on their own.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

The person is difficult to wake, breathing is slow or abnormal, lips become blue or grey, they vomit while consciousness is impaired, or they do not respond.

Call 112

Main risks

What matters most

  • Memory loss, falls, and accidents
  • Respiratory depression and coma when mixed
  • Severe withdrawal and seizures if stopped suddenly

Mixing

Combining with other substances

Opioids, alcohol, GHB/GBL, and other depressants can cause profound sedation, respiratory depression, coma, and death.

Effects and risk reduction

Effects and safer use

Common effects

Reduced anxiety, relaxation, drowsiness, slower reactions, and sometimes memory loss or impaired judgement.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you
  • A tablet's appearance, imprint, or name does not confirm its contents
  • Do not stop suddenly after regular use; seek medical advice

Chemistry

Chemical structure

PubChem
2D structural formula: Alprazolam. 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
AlprazolamC17H13ClN4
PubChem · CID 2118
Exact molecular identity

8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Alprazolam is a benzodiazepine that can reduce anxiety but can also cause drowsiness, unsteadiness, impaired judgement, and memory loss. A person may appear awake but remember very little later.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table republishes only the existing community-reported ranges for alprazolam. It is not medical dosing advice and must not be used to convert to diazepam or another benzodiazepine. Opioids, alcohol, and other depressants increase the risk of respiratory depression, coma, and death.

Alprazolam by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 22 July 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. The amounts apply only to alprazolam and the route shown in the same row. Counterfeit tablets may contain another benzodiazepine, a research chemical, or an opioid.

Alprazolam

RouteInhaled

Threshold
0.05 mg
Light
0.05–0.25 mg
Common
0.25–0.5 mg
Strong
0.5–1 mg
Heavy
≥1 mg

Note: This unusual route appears in the community-reported source but is not medically verified or recommended.

Alprazolam

RouteOral

Threshold
0.1 mg
Light
0.25–0.5 mg
Common
0.5–1.5 mg
Strong
1.5–2 mg
Heavy
≥2 mg

Note: Short-acting and a common name on counterfeit tablets.

If the experience becomes an emergency

Emergency steps for Alprazolam
  1. Stop all further use and do not give food, drink, or any other substances.
  2. Check responsiveness and breathing. Call 112 if the person is difficult to wake, is breathing abnormally, vomits while their consciousness is impaired, or has a seizure.
  3. If the person is breathing normally, place them in the recovery position and monitor their breathing continuously.
  4. Give naloxone only when opioid use is suspected. Naloxone does not reverse alcohol, GHB, or benzodiazepines on their own.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

The person is difficult to wake, breathing is slow or abnormal, lips become blue or grey, they vomit while consciousness is impaired, or they do not respond.

Call 112

Main risks

What matters most

  • Prolonged drowsiness, falls, and road traffic accidents
  • Respiratory depression and coma when mixed
  • Severe withdrawal and seizures if stopped suddenly

Mixing

Combining with other substances

Opioids, alcohol, GHB/GBL, and other depressants can cause profound sedation, respiratory depression, coma, and death.

Effects and risk reduction

Effects and safer use

Common effects

Reduced anxiety, muscle relaxation, drowsiness, slower reactions, and impaired balance or memory.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you
  • Do not drive if you feel drowsy or slowed down, including the next day
  • Do not stop suddenly after regular use; seek medical advice

Chemistry

Chemical structure

PubChem
2D structural formula: Diazepam. 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
DiazepamC16H13ClN2O
PubChem · CID 3016
Exact molecular identity

7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Diazepam is a benzodiazepine that can cause calm, muscle relaxation, and drowsiness, as well as impaired memory and balance. With deeper sedation, a person becomes harder to wake and less able to protect their airway.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table republishes only the existing community-reported ranges for oral diazepam. It is not medical dosing advice and must not be used to convert to alprazolam or another benzodiazepine. Opioids, alcohol, and other depressants increase the risk of respiratory depression, coma, and death.

Diazepam by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 22 July 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. The amount applies only to oral diazepam. Milligrams are not equivalent across benzodiazepines.

Diazepam

RouteOral

Threshold
1 mg
Light
2.5–5 mg
Common
5–15 mg
Strong
15–30 mg
Heavy
≥30 mg

Note: Long-acting metabolites can accumulate over several days.

If the experience becomes an emergency

Emergency steps for Diazepam
  1. Stop all further use and do not give food, drink, or any other substances.
  2. Check responsiveness and breathing. Call 112 if the person is difficult to wake, is breathing abnormally, vomits while their consciousness is impaired, or has a seizure.
  3. If the person is breathing normally, place them in the recovery position and monitor their breathing continuously.
  4. Give naloxone only when opioid use is suspected. Naloxone does not reverse alcohol, GHB, or benzodiazepines on their own.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

The person is difficult to wake, breathing is slow or abnormal, lips become blue or grey, they vomit while consciousness is impaired, or they do not respond.

Call 112

Main risks

What matters most

  • Memory loss, falls, and accidents
  • Respiratory depression and coma when mixed
  • Severe withdrawal and seizures if stopped suddenly

Mixing

Combining with other substances

Opioids, alcohol, GHB/GBL, and other depressants can cause profound sedation, respiratory depression, coma, and death.

Effects and risk reduction

Effects and safer use

Common effects

Relaxation, drowsiness, slower reactions, unsteadiness, and memory loss.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you
  • Do not leave your drink unattended and seek help immediately if you suspect drink spiking
  • Do not stop suddenly after regular use; seek medical advice

Chemistry

Chemical structure

PubChem
2D structural formula: Flunitrazepam. 5-(2-fluorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one
FlunitrazepamC16H12FN3O3
PubChem · CID 3380
Exact molecular identity

5-(2-fluorophenyl)-1-methyl-7-nitro-3H-1,4-benzodiazepin-2-one

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, emergency steps and sources

What the experience may feel like

Flunitrazepam is a highly potent benzodiazepine that can cause profound drowsiness, unsteadiness, impaired judgement, and memory loss. A person may appear awake but remember little or nothing later.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose information

No numerical dose table is published. Milligrams are not equivalent across benzodiazepines, and a tablet marked Rohypnol confirms neither its contents nor strength outside a secure medicine supply chain.

If the experience becomes an emergency

Emergency steps for Flunitrazepam
  1. Stop all further use and do not give food, drink, or any other substances.
  2. Check responsiveness and breathing. Call 112 if the person is difficult to wake, is breathing abnormally, vomits while their consciousness is impaired, or has a seizure.
  3. If the person is breathing normally, place them in the recovery position and monitor their breathing continuously.
  4. Give naloxone only when opioid use is suspected. Naloxone does not reverse alcohol, GHB, or benzodiazepines on their own.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

The person is difficult to wake, breathing is slow or abnormal, lips become blue or grey, they vomit while consciousness is impaired, or they do not respond.

Call 112

Main risks

What matters most

  • Memory loss, falls, and accidents
  • Respiratory depression and coma when mixed
  • Severe withdrawal and seizures if stopped suddenly

Mixing

Combining with other substances

Opioids, alcohol, GHB/GBL, and other depressants can cause profound sedation, respiratory depression, coma, and death.

Effects and risk reduction

Effects and safer use

Common effects

Reduced anxiety, relaxation, drowsiness, slower reactions, and impaired coordination.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you
  • Do not drive or operate machinery if you feel drowsy or slowed down
  • Do not stop suddenly after regular use; seek medical advice

Chemistry

Chemical structure

PubChem
2D structural formula: Bromazepam. 7-bromo-5-pyridin-2-yl-1,3-dihydro-1,4-benzodiazepin-2-one
BromazepamC14H10BrN3O
PubChem · CID 2441
Exact molecular identity

7-bromo-5-pyridin-2-yl-1,3-dihydro-1,4-benzodiazepin-2-one

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, emergency steps and sources

What the experience may feel like

Bromazepam is an anti-anxiety benzodiazepine that can also cause drowsiness, dizziness, unsteadiness, impaired judgement, and memory loss.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose information

No numerical dose table is published. Milligrams of bromazepam are not equivalent to milligrams of another benzodiazepine, and unknown tablets may contain another substance or strength.

If the experience becomes an emergency

Emergency steps for Bromazepam
  1. Stop all further use and do not give food, drink, or any other substances.
  2. Check responsiveness and breathing. Call 112 if the person is difficult to wake, is breathing abnormally, vomits while their consciousness is impaired, or has a seizure.
  3. If the person is breathing normally, place them in the recovery position and monitor their breathing continuously.
  4. Give naloxone only when opioid use is suspected. Naloxone does not reverse alcohol, GHB, or benzodiazepines on their own.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

The person is difficult to wake, breathing is slow or abnormal, lips become blue or grey, they vomit while consciousness is impaired, or they do not respond.

Call 112

Main risks

What matters most

  • Prolonged drowsiness, falls, and accidents
  • Respiratory depression and coma when mixed
  • Severe withdrawal and seizures if stopped suddenly

Mixing

Combining with other substances

Opioids, alcohol, GHB/GBL, and other depressants can cause profound sedation, respiratory depression, coma, and death.

Effects and risk reduction

Effects and safer use

Common effects

Relaxation, drowsiness, slower reactions, unsteadiness, and impaired memory.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you
  • Do not drive if you feel drowsy or slowed down, including the next day
  • Do not stop suddenly after regular use; seek medical advice

Chemistry

Chemical structure

PubChem
2D structural formula: Clonazepam. 5-(2-chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one
ClonazepamC15H10ClN3O3
PubChem · CID 2802
Exact molecular identity

5-(2-chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, emergency steps and sources

What the experience may feel like

Clonazepam is a long-acting benzodiazepine that can cause calm and drowsiness, as well as unsteadiness, impaired judgement, and memory loss. With deeper sedation, a person becomes harder to wake and less able to protect their airway.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose information

No numerical dose table is published. Milligrams of clonazepam are not equivalent to milligrams of another benzodiazepine. Opioids, alcohol, and other depressants increase the risk of respiratory depression, coma, and death.

If the experience becomes an emergency

Emergency steps for Clonazepam
  1. Stop all further use and do not give food, drink, or any other substances.
  2. Check responsiveness and breathing. Call 112 if the person is difficult to wake, is breathing abnormally, vomits while their consciousness is impaired, or has a seizure.
  3. If the person is breathing normally, place them in the recovery position and monitor their breathing continuously.
  4. Give naloxone only when opioid use is suspected. Naloxone does not reverse alcohol, GHB, or benzodiazepines on their own.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

The person is difficult to wake, breathing is slow or abnormal, lips become blue or grey, they vomit while consciousness is impaired, or they do not respond.

Call 112

Main risks

What matters most

  • Drowsiness, falls, and accidents
  • Respiratory depression and coma when mixed
  • Severe withdrawal and seizures if stopped suddenly

Mixing

Combining with other substances

Opioids, alcohol, GHB/GBL, and other depressants can cause profound sedation, respiratory depression, coma, and death.

Effects and risk reduction

Effects and safer use

Common effects

Reduced anxiety, relaxation, drowsiness, dizziness, and slower reactions.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you
  • Do not drive or operate machinery if you feel drowsy or dizzy
  • Do not stop suddenly after regular use; seek medical advice

Chemistry

Chemical structure

PubChem
2D structural formula: Oxazepam. 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
OxazepamC15H11ClN2O2
PubChem · CID 4616
Exact molecular identity

7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, emergency steps and sources

What the experience may feel like

Oxazepam is an anti-anxiety benzodiazepine that can cause calm and drowsiness, as well as dizziness, impaired coordination, unsteadiness, and memory loss.

Duration by route

Route-specific timing could not be verified from PsychonautWiki for this substance. No figures are inferred from other substances or routes.

Source: PsychonautWiki · Data retrieved

Dose information

No numerical dose table is published. Milligrams of oxazepam are not equivalent to milligrams of another benzodiazepine. Opioids, alcohol, and other depressants increase the risk of respiratory depression, coma, and death.

If the experience becomes an emergency

Emergency steps for Oxazepam
  1. Stop all further use and do not give food, drink, or any other substances.
  2. Check responsiveness and breathing. Call 112 if the person is difficult to wake, is breathing abnormally, vomits while their consciousness is impaired, or has a seizure.
  3. If the person is breathing normally, place them in the recovery position and monitor their breathing continuously.
  4. Give naloxone only when opioid use is suspected. Naloxone does not reverse alcohol, GHB, or benzodiazepines on their own.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

The person is difficult to wake, breathing is slow or abnormal, lips become blue or grey, they vomit while consciousness is impaired, or they do not respond.

Call 112

Main risks

What matters most

  • Next-day drowsiness, falls, and road traffic accidents
  • Respiratory depression and coma when mixed
  • Severe withdrawal and seizures if stopped suddenly

Mixing

Combining with other substances

Opioids, alcohol, GHB/GBL, and other depressants can cause profound sedation, respiratory depression, coma, and death.

Effects and risk reduction

Effects and safer use

Common effects

Drowsiness, relaxation, slower reactions, unsteadiness, and memory loss.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you
  • Do not drive if you feel drowsy or slowed down, including the next day
  • Do not stop suddenly after regular use; seek medical advice

Chemistry

Chemical structure

PubChem
2D structural formula: Nitrazepam. 7-nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
NitrazepamC15H11N3O3
PubChem · CID 4506
Exact molecular identity

7-nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, emergency steps and sources

What the experience may feel like

Nitrazepam is a benzodiazepine sleeping medicine that can cause profound drowsiness, unsteadiness, impaired coordination, and memory loss.

Duration by route

Route-specific timing could not be verified from PsychonautWiki for this substance. No figures are inferred from other substances or routes.

Source: PsychonautWiki · Data retrieved

Dose information

No numerical dose table is published. Milligrams of nitrazepam are not equivalent to milligrams of another benzodiazepine. Opioids, alcohol, and other depressants increase the risk of respiratory depression, coma, and death.

If the experience becomes an emergency

Emergency steps for Nitrazepam
  1. Stop all further use and do not give food, drink, or any other substances.
  2. Check responsiveness and breathing. Call 112 if the person is difficult to wake, is breathing abnormally, vomits while their consciousness is impaired, or has a seizure.
  3. If the person is breathing normally, place them in the recovery position and monitor their breathing continuously.
  4. Give naloxone only when opioid use is suspected. Naloxone does not reverse alcohol, GHB, or benzodiazepines on their own.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

The person is difficult to wake, breathing is slow or abnormal, lips become blue or grey, they vomit while consciousness is impaired, or they do not respond.

Call 112

Main risks

What matters most

  • Prolonged drowsiness, falls, and accidents
  • Respiratory depression and coma when mixed
  • Severe withdrawal and seizures if stopped suddenly

Mixing

Combining with other substances

Opioids, alcohol, GHB/GBL, and other depressants can cause profound sedation, respiratory depression, coma, and death.

Effects and risk reduction

Effects and safer use

Common effects

Reduced anxiety, relaxation, drowsiness, slower reactions, and impaired balance.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you
  • Do not drive if you feel drowsy or slowed down, including the next day
  • Do not stop suddenly after regular use; seek medical advice

Chemistry

Chemical structure

PubChem
2D structural formula: Chlordiazepoxide. 7-chloro-4-hydroxy-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-imine
ChlordiazepoxideC16H14ClN3O
PubChem · CID 2712
Exact molecular identity

7-chloro-4-hydroxy-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-imine

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, emergency steps and sources

What the experience may feel like

Chlordiazepoxide is a long-acting benzodiazepine that can cause calm and drowsiness, as well as unsteadiness, impaired coordination, and memory loss.

Duration by route

Route-specific timing could not be verified from PsychonautWiki for this substance. No figures are inferred from other substances or routes.

Source: PsychonautWiki · Data retrieved

Dose information

No numerical dose table is published. Milligrams of chlordiazepoxide are not equivalent to milligrams of another benzodiazepine. Opioids, alcohol, and other depressants increase the risk of respiratory depression, coma, and death.

If the experience becomes an emergency

Emergency steps for Chlordiazepoxide
  1. Stop all further use and do not give food, drink, or any other substances.
  2. Check responsiveness and breathing. Call 112 if the person is difficult to wake, is breathing abnormally, vomits while their consciousness is impaired, or has a seizure.
  3. If the person is breathing normally, place them in the recovery position and monitor their breathing continuously.
  4. Give naloxone only when opioid use is suspected. Naloxone does not reverse alcohol, GHB, or benzodiazepines on their own.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

The person is difficult to wake, breathing is slow or abnormal, lips become blue or grey, they vomit while consciousness is impaired, or they do not respond.

Call 112

Main risks

What matters most

  • Memory loss and complex sleep behaviours
  • Respiratory depression and coma when mixed
  • Severe withdrawal and seizures if stopped suddenly

Mixing

Combining with other substances

Opioids, alcohol, GHB/GBL, and other depressants can cause profound sedation, respiratory depression, coma, and death.

Effects and risk reduction

Effects and safer use

Common effects

Drowsiness, relaxation, slower reactions, impaired coordination, and memory loss.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you
  • Do not drive or do hazardous tasks if you feel drowsy or have poor memory of the night
  • Do not stop suddenly after regular use; seek medical advice

Chemistry

Chemical structure

PubChem
2D structural formula: Triazolam (Halcion). 8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
Triazolam (Halcion)C17H12Cl2N4
PubChem · CID 5556
Exact molecular identity

8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, emergency steps and sources

What the experience may feel like

Triazolam, sold under the brand name Halcion, is a short-acting benzodiazepine sleeping medicine. It can cause profound drowsiness, impaired coordination, memory loss, and complex sleep behaviours that a person does not remember later.

Duration by route

Route-specific timing could not be verified from PsychonautWiki for this substance. No figures are inferred from other substances or routes.

Source: PsychonautWiki · Data retrieved

Dose information

No numerical dose table is published. Milligrams of triazolam are not equivalent to milligrams of another benzodiazepine. Opioids, alcohol, and other depressants increase the risk of respiratory depression, coma, and death.

If the experience becomes an emergency

Emergency steps for Triazolam (Halcion)
  1. Stop all further use and do not give food, drink, or any other substances.
  2. Check responsiveness and breathing. Call 112 if the person is difficult to wake, is breathing abnormally, vomits while their consciousness is impaired, or has a seizure.
  3. If the person is breathing normally, place them in the recovery position and monitor their breathing continuously.
  4. Give naloxone only when opioid use is suspected. Naloxone does not reverse alcohol, GHB, or benzodiazepines on their own.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Difficult to wake, irregular breathing, seizures, pale or bluish skin, or repeated vomiting.

Call 112

Main risks

What matters most

  • Alcohol poisoning
  • Accidents, violence, and drowning
  • Liver, heart, and nerve damage from long-term use

Mixing

Combining with other substances

Do not combine with opioids, benzodiazepines, GHB/GBL, or other depressant medicines.

Effects and risk reduction

Effects and safer use

Common effects

Relaxation and greater social ease, but also impaired judgement, balance, and reactions.

If you choose to use
  • Eat food and drink water as well
  • Avoid rapid drinking and drinking competitions
  • Never leave a person with impaired consciousness alone

Chemistry

Chemical structure

PubChem
2D structural formula: Alcohol. ethanol
AlcoholC2H6O
PubChem · CID 702
Exact molecular identity

ethanol

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

At lower amounts, alcohol can increase social ease and relaxation. As the amount rises, reactions, balance, speech, memory, and judgement become impaired; a very large amount can suppress breathing and the body’s protective reflexes.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: Ethanol is shown in WHO alcohol units, where 1 unit equals 10 g of pure ethanol. Drink type, speed, food, physical condition, medicines, and tolerance change the effects, and no amount is risk-free.

Alcohol in WHO alcohol units

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 22 July 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. One WHO alcohol unit is defined here as 10 g of pure ethanol. A unit says nothing about drinking speed, alcohol concentration, physical condition, or dangerous combinations, and no amount of alcohol is risk-free.

Ethanol

RouteOral

Threshold
1 unit
Light
1–2 units
Common
2–3 units
Strong
3–4 units
Heavy
≥4 units

Note: The ranges were converted directly from grams using 1 unit = 10 g; no new thresholds were calculated.

If the experience becomes an emergency

Emergency steps for Alcohol
  1. Call 112 if the person is difficult to wake, is breathing irregularly, has a seizure, is cold and clammy, or vomits while their consciousness is impaired.
  2. If the person is breathing normally, place them in the recovery position and monitor their breathing continuously.
  3. Do not give coffee, food, a cold shower, or more alcohol, and do not try to make the person walk it off.
  4. Stay with the person until help arrives. Blood alcohol concentration can continue to rise after the last drink.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

A person is unresponsive, breathing abnormally, vomiting while unconscious, or having a seizure.

Call 112

Main risks

What matters most

  • Sudden unconsciousness
  • Breathing impairment and vomiting
  • Severe withdrawal with frequent use

Mixing

Combining with other substances

Never combine with alcohol, opioids, benzodiazepines, or other depressants.

Effects and risk reduction

Effects and safer use

Common effects

Relaxation, drowsiness, euphoria, and reduced inhibitions.

If you choose to use
  • Do not use alone
  • Millilitres do not indicate the amount of GHB, and GHB, GBL, and 1,4-BDO are not equivalent
  • Keep the substance clearly labelled and away from other people's drinks
  • Seek medical help for withdrawal after frequent use

Chemistry

Chemical structure

PubChem
2D structural formula: GHB. 4-hydroxybutanoic acid
GHBC4H8O3
PubChem · CID 10413
Exact molecular identity

4-hydroxybutanoic acid

2D structural formula: GBL. oxolan-2-one
GBLC4H6O2
PubChem · CID 7302
Exact molecular identity

oxolan-2-one

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Milder effects can include relaxation, social disinhibition, and euphoria. A very small margin can separate that experience from sudden drowsiness, vomiting, memory loss, or unconsciousness.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table separates GHB measured in grams from GBL measured in millilitres. The substances and units are not interchangeable, and a liquid of unknown concentration makes the figures unusable.

GHB and GBL by substance

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 10 September 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. GHB and GBL are different substances, and grams of GHB must never be treated as millilitres of GBL. Unknown concentration or contents make every figure unusable.

GHB

RouteOral

Threshold
0.5 g
Light
0.5–1 g
Common
1–2.5 g
Strong
2.5–4 g
Heavy
≥4 g

Note: PsychonautWiki warns of a risk of death above 10 g, but severe poisoning can occur at a lower amount.

GBL

RouteOral

Threshold
0.3 mL
Light
0.3–0.9 mL
Common
0.9–1.5 mL
Strong
1.5–3 mL
Heavy
≥3 mL

Note: The source warns that amounts above 2 mL can cause profound sleep. The concentration and contents of a liquid are often unknown.

If the experience becomes an emergency

Emergency steps for GHB / GBL
  1. Stop all further use and do not give food, drink, or any other substances.
  2. Check responsiveness and breathing. Call 112 if the person is difficult to wake, is breathing abnormally, vomits while their consciousness is impaired, or has a seizure.
  3. If the person is breathing normally, place them in the recovery position and monitor their breathing continuously.
  4. Give naloxone only when opioid use is suspected. Naloxone does not reverse alcohol, GHB, or benzodiazepines on their own.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Severe drowsiness; slow, shallow, or difficult breathing; blue lips; seizures; or no response.

Call 112

Main risks

What matters most

  • Breathing impairment when combined with other substances
  • Falls, accidents, and impaired consciousness
  • Dependence and withdrawal

Mixing

Combining with other substances

Opioids, alcohol, benzodiazepines, and other depressants increase the risk of unconsciousness and impaired breathing.

Effects and risk reduction

Effects and safer use

Common effects

Drowsiness, dizziness, unsteadiness, and impaired coordination. Morphine and other depressants can increase its effects and risks.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you
  • Do not drive if you feel drowsy or dizzy
  • Doses may need adjustment with impaired kidney function; seek medical advice before stopping regular use

Chemistry

Chemical structure

PubChem
2D structural formula: Gabapentin. 2-[1-(aminomethyl)cyclohexyl]acetic acid
GabapentinC9H17NO2
PubChem · CID 3446
Exact molecular identity

2-[1-(aminomethyl)cyclohexyl]acetic acid

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, emergency steps and sources

What the experience may feel like

Gabapentin is a medicine used for seizures and nerve pain that can cause drowsiness, dizziness, unsteadiness, and impaired coordination. Serious or fatal respiratory depression has occurred, especially with opioids, other depressants, or underlying breathing problems.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose information

No numerical dose table is published for gabapentin. It is prescribed individually according to the condition being treated, kidney function, and other medicines; pregabalin amounts do not apply to gabapentin. Morphine and other opioids can increase sedation and the risk of respiratory depression.

If the experience becomes an emergency

Emergency steps for Gabapentin
  1. Stop all further use and do not give food, drink, or any other substances.
  2. Check responsiveness and breathing. Call 112 if the person is difficult to wake, is breathing abnormally, vomits while their consciousness is impaired, or has a seizure.
  3. If the person is breathing normally, place them in the recovery position and monitor their breathing continuously.
  4. Give naloxone only when opioid use is suspected. Naloxone does not reverse alcohol, GHB, or benzodiazepines on their own.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Severe drowsiness; slow, shallow, or difficult breathing; blue lips; seizures; or no response.

Call 112

Main risks

What matters most

  • Serious or fatal breathing impairment when combined with other substances
  • Falls, accidents, and impaired consciousness
  • Dependence and withdrawal

Mixing

Combining with other substances

Opioids, alcohol, benzodiazepines, and other depressants increase the risk of unconsciousness, impaired breathing, and death.

Effects and risk reduction

Effects and safer use

Common effects

Calm, drowsiness, dizziness, unsteadiness, and impaired coordination. Effects can become much stronger with other depressants.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you
  • Do not drive if you feel drowsy or dizzy
  • Doses may need adjustment with impaired kidney function; seek medical advice before stopping regular use

Chemistry

Chemical structure

PubChem
2D structural formula: Pregabalin. (3S)-3-(aminomethyl)-5-methylhexanoic acid
PregabalinC8H17NO2
PubChem · CID 5486971
Exact molecular identity

(3S)-3-(aminomethyl)-5-methylhexanoic acid

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Pregabalin is a medicine used for seizures and nerve pain that can cause calm, drowsiness, dizziness, unsteadiness, and impaired coordination. Serious or fatal respiratory depression has occurred, especially with opioids, other depressants, or underlying breathing problems.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table republishes only the existing community-reported ranges for pregabalin. It is not medical dosing advice and does not apply to gabapentin. An individual prescription, kidney function, and other medicines change the risk; opioids and other depressants can increase the risk of respiratory depression.

Pregabalin by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 22 July 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. The table applies only to pregabalin and does not apply to gabapentin. It is not medical dosing advice; kidney function and other medicines change the risk.

Pregabalin

RouteOral

Threshold
50 mg
Light
50–225 mg
Common
225–600 mg
Strong
600–900 mg
Heavy
≥900 mg

Note: Opioids and other depressants increase the risk of impaired breathing.

Pregabalin

RouteRectal

Threshold
<40 mg
Light
40–200 mg
Common
200–450 mg
Strong
450–600 mg
Heavy
≥600 mg

Note: An unusual route from a community-reported source; not medically verified or recommended.

If the experience becomes an emergency

Emergency steps for Pregabalin
  1. Stop all further use and do not give food, drink, or any other substances.
  2. Check responsiveness and breathing. Call 112 if the person is difficult to wake, is breathing abnormally, vomits while their consciousness is impaired, or has a seizure.
  3. If the person is breathing normally, place them in the recovery position and monitor their breathing continuously.
  4. Give naloxone only when opioid use is suspected. Naloxone does not reverse alcohol, GHB, or benzodiazepines on their own.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

The person is difficult to wake, breathing is slow or abnormal, they have a seizure, vomit while consciousness is impaired, or show dangerous behaviour while not fully awake.

Call 112

Main risks

What matters most

  • Memory loss, falls, and road traffic accidents
  • Complex sleep behaviour while not fully awake
  • Dependence, tolerance, and withdrawal

Mixing

Combining with other substances

Alcohol, opioids, benzodiazepines, GHB/GBL, and other depressant medicines or substances can cause profound sedation, respiratory depression, coma, and death.

Effects and risk reduction

Effects and safer use

Common effects

Drowsiness, relaxation, dizziness, unsteadiness, and impaired attention or memory. A bitter or metallic taste is common, and impairment can continue into the next day.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you
  • Do not take another dose during the same night and do not drive if you are drowsy
  • Stop taking it and contact a healthcare professional immediately if complex sleep behaviour occurs

Chemistry

Chemical structure

PubChem
2D structural formula: Imovane (zopiclone). [6-(5-chloro-2-pyridinyl)-5-oxo-7H-pyrrolo[3,4-b]pyrazin-7-yl] 4-methylpiperazine-1-carboxylate
Imovane (zopiclone)C17H17ClN6O3
PubChem · CID 5735
Exact molecular identity

[6-(5-chloro-2-pyridinyl)-5-oxo-7H-pyrrolo[3,4-b]pyrazin-7-yl] 4-methylpiperazine-1-carboxylate

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Zopiclone can cause drowsiness, relaxation, dizziness, unsteadiness, and memory loss. A bitter or metallic taste is common, and some people carry out complex activities while asleep without remembering them.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table republishes PsychonautWiki’s user-reported ranges for oral zopiclone. It is not medical dosing advice or a safety limit. Imovane contains zopiclone and should only be taken as prescribed to you. Tolerance, dependence, and withdrawal can occur with repeated use.

Zopiclone by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 10 September 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. The table applies only to oral zopiclone. Imovane is a prescription medicine and should only be taken as prescribed to you.

Zopiclone

RouteOral

Threshold
2 mg
Light
3.5–5 mg
Common
5–7.5 mg
Strong
7.5–15 mg
Heavy
≥15 mg

Note: Memory loss, complex sleep behaviour, and impaired breathing become more likely with alcohol, opioids, and other depressants.

If the experience becomes an emergency

Emergency steps for Imovane (zopiclone)
  1. Stop all further use and do not give food, drink, or any other medicine or substance.
  2. Call the Poison Information Centre on 543 2222 if more than prescribed may have been taken, a child may have taken the medicine, or the mixture is unknown. Do not wait for symptoms.
  3. Call 112 immediately if the person is difficult to wake, breathing is slow or abnormal, their lips become blue or grey, they have a seizure, or they collapse.
  4. If the person is breathing normally, place them in the recovery position, monitor their breathing continuously, and follow the instructions from 112. Naloxone does not reverse zopiclone or zolpidem on its own, but may be given if opioid use is also suspected.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

The person is difficult to wake, breathing is slow or abnormal, they have a seizure, vomit while consciousness is impaired, or show dangerous behaviour while not fully awake.

Call 112

Main risks

What matters most

  • Memory loss, falls, and road traffic accidents
  • Complex sleep behaviour that can cause serious injury
  • Dependence, tolerance, and withdrawal

Mixing

Combining with other substances

Alcohol, opioids, benzodiazepines, GHB/GBL, and other depressant medicines or substances can cause profound sedation, respiratory depression, coma, and death.

Effects and risk reduction

Effects and safer use

Common effects

Drowsiness, relaxation, dizziness, slower reactions, impaired coordination, confusion, and memory loss. Impaired alertness can continue into the next day.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you
  • Do not take another dose during the same night and do not drive if you are drowsy
  • Stop taking it and contact a healthcare professional immediately if complex sleep behaviour occurs

Chemistry

Chemical structure

PubChem
2D structural formula: Stilnoct (zolpidem). N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide
Stilnoct (zolpidem)C19H21N3O
PubChem · CID 5732
Exact molecular identity

N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Zolpidem can cause drowsiness, relaxation, dizziness, confusion, unsteadiness, and memory loss. Complex sleep behaviour, such as sleepwalking or driving while not fully awake, can occur without the person remembering it.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table republishes PsychonautWiki’s user-reported ranges for oral zolpidem. It is not medical dosing advice or a safety limit. Stilnoct contains zolpidem and should only be taken as prescribed to you. Tolerance, dependence, and withdrawal can occur with repeated use.

Zolpidem by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 10 September 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. The table applies only to oral zolpidem. Stilnoct is a prescription medicine and should only be taken as prescribed to you.

Zolpidem

RouteOral

Threshold
5 mg
Light
10–20 mg
Common
20–30 mg
Strong
30–50 mg
Heavy
≥50 mg

Note: Memory loss, complex sleep behaviour, and impaired breathing become more likely with alcohol, opioids, and other depressants.

If the experience becomes an emergency

Emergency steps for Stilnoct (zolpidem)
  1. Stop all further use and do not give food, drink, or any other medicine or substance.
  2. Call the Poison Information Centre on 543 2222 if more than prescribed may have been taken, a child may have taken the medicine, or the mixture is unknown. Do not wait for symptoms.
  3. Call 112 immediately if the person is difficult to wake, breathing is slow or abnormal, their lips become blue or grey, they have a seizure, or they collapse.
  4. If the person is breathing normally, place them in the recovery position, monitor their breathing continuously, and follow the instructions from 112. Naloxone does not reverse zopiclone or zolpidem on its own, but may be given if opioid use is also suspected.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Stimulants

8

Urgent warning

Call 112 if

Chest pain, very high temperature, a seizure, a sudden severe headache, difficulty breathing, or severe confusion.

Call 112

Main risks

What matters most

  • Overheating and dehydration
  • Heart and circulation problems
  • Psychosis, anxiety, and exhaustion

Mixing

Combining with other substances

Other stimulants increase strain on the heart and raise body temperature. Depressants do not “cancel out” the effects and can hide warning signs.

Effects and risk reduction

Effects and safer use

Common effects

Energy, focus, reduced appetite and need for sleep; sometimes anxiety and repetitive behaviour.

If you choose to use
  • Take breaks, cool down, and drink regularly but not excessively
  • Avoid staying awake for long periods
  • Do not use alone

Chemistry

Chemical structure

PubChem
2D structural formula: Amphetamine. 1-phenylpropan-2-amine
AmphetamineC9H13N
PubChem · CID 3007
Exact molecular identity

1-phenylpropan-2-amine

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Energy, wakefulness, concentration, and confidence can increase. With stronger effects, jaw tension, sweating, a racing heart, repetitive behaviour, anxiety, and suspiciousness become more common; sleep deprivation increases the risk of psychosis.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table applies only to verified amphetamine and the listed routes. It does not apply to methamphetamine or street powder of unknown purity.

Amphetamine by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 22 July 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. The table applies only to verified amphetamine. It does not apply to methamphetamine or street powder of unknown purity.

Amphetamine

RouteOral

Threshold
2.5 mg
Light
5–10 mg
Common
10–25 mg
Strong
25–50 mg
Heavy
≥50 mg

Note: Applies only to verified amphetamine.

Amphetamine

RouteIntranasal

Threshold
4 mg
Light
6–15 mg
Common
15–30 mg
Strong
30–50 mg
Heavy
≥50 mg

Note: The purity of street powder is generally unknown.

Amphetamine

RouteIntravenous

Threshold
4 mg
Light
6–15 mg
Common
15–30 mg
Strong
30–50 mg
Heavy
≥50 mg

Note: Very rapid onset and increased risk of overdose, infection, and vein damage.

If the experience becomes an emergency

Emergency steps for Amphetamine
  1. Stop further use and move the person to a calm, cool, and safe environment.
  2. Loosen tight clothing and cool them gently. Do not force a large amount of fluid at once, and do not give other substances in an attempt to balance the effects.
  3. Call 112 for chest pain, a seizure, a very high temperature, severe confusion, difficulty breathing, or sudden weakness on one side.
  4. Stay with the person, monitor their breathing, and follow the instructions from 112.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Chest pain, fainting, a seizure, very high temperature, a fast or irregular pulse, hallucinations, or severe confusion.

Call 112

Main risks

What matters most

  • Increased heart rate, blood pressure, and strain on the heart
  • Anxiety, insomnia, and psychiatric symptoms
  • Misuse, addiction, and overdose

Mixing

Combining with other substances

MAO inhibitors can cause a life-threatening rise in blood pressure. Other stimulants and serotonergic substances or medicines can increase strain on the heart, overheating, seizure risk, and serotonin syndrome.

Effects and risk reduction

Effects and safer use

Common effects

Increased alertness and concentration, reduced appetite and need for sleep; anxiety, restlessness, and a racing heart can also occur.

If you choose to use
  • Take it only according to your own prescription
  • Do not share it or use medicine prescribed to someone else
  • Store it securely and discuss strong or troubling symptoms with a doctor or pharmacist

Chemistry

Chemical structure

PubChem
2D structural formula: Lisdexamfetamine. (2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanamide
LisdexamfetamineC15H25N3O
PubChem · CID 11597698
Exact molecular identity

(2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanamide

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, emergency steps and sources

What the experience may feel like

Lisdexamfetamine is a prodrug that is converted to dextroamphetamine in the blood. When taken as prescribed it can improve concentration and alertness, but it can also reduce appetite and cause insomnia, anxiety, a racing heart, and higher blood pressure.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose information

No dose figure is published. Milligrams of lisdexamfetamine are not equivalent milligram-for-milligram to dextroamphetamine, and dosing must follow an individual prescription.

If the experience becomes an emergency

Emergency steps for Lisdexamfetamine
  1. Stop further use and move the person to a calm, cool, and safe environment.
  2. Loosen tight clothing and cool them gently. Do not force a large amount of fluid at once, and do not give other substances in an attempt to balance the effects.
  3. Call 112 for chest pain, a seizure, a very high temperature, severe confusion, difficulty breathing, or sudden weakness on one side.
  4. Stay with the person, monitor their breathing, and follow the instructions from 112.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Chest pain, fainting, a seizure, very high temperature, difficulty breathing, hallucinations, or sudden severe confusion.

Call 112

Main risks

What matters most

  • Heart and blood-pressure problems
  • Psychosis, mania, seizures, and overheating
  • Misuse, addiction, and overdose

Mixing

Combining with other substances

Do not use with MAO inhibitors. Other stimulants and serotonergic substances or medicines can increase blood pressure, overheating, seizure risk, and serotonin syndrome.

Effects and risk reduction

Effects and safer use

Common effects

Increased alertness, concentration, and energy with reduced appetite; tremor, anxiety, restlessness, and insomnia can also occur.

If you choose to use
  • Take it only according to your own prescription
  • Do not increase the amount or frequency without speaking to your prescriber
  • Do not share it and store it where other people cannot access it

Chemistry

Chemical structure

PubChem
2D structural formula: Dextroamphetamine. (2S)-1-phenylpropan-2-amine
DextroamphetamineC9H13N
PubChem · CID 5826
Exact molecular identity

(2S)-1-phenylpropan-2-amine

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, emergency steps and sources

What the experience may feel like

Dextroamphetamine can increase concentration, alertness, and energy, but can also cause reduced appetite, tremor, sweating, anxiety, insomnia, and a faster pulse. Psychotic or manic symptoms can occur even during prescribed use.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose information

No dose figure is published. Immediate-release and extended-release products are not interchangeable, and dosing must follow an individual prescription from a healthcare professional.

If the experience becomes an emergency

Emergency steps for Dextroamphetamine
  1. Stop further use and move the person to a calm, cool, and safe environment.
  2. Loosen tight clothing and cool them gently. Do not force a large amount of fluid at once, and do not give other substances in an attempt to balance the effects.
  3. Call 112 for chest pain, a seizure, a very high temperature, severe confusion, difficulty breathing, or sudden weakness on one side.
  4. Stay with the person, monitor their breathing, and follow the instructions from 112.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Chest pain, very high temperature, a seizure, a sudden severe headache, severe confusion, impaired consciousness, or signs of stroke.

Call 112

Main risks

What matters most

  • Overheating, heart attack, and stroke
  • Prolonged sleep deprivation, psychosis, and exhaustion
  • Compulsive redosing and addiction

Mixing

Combining with other substances

Other stimulants increase the risk of overheating and cardiac or neurological emergencies. Opioids and other depressants can hide warning signs and increase the risk of a fatal overdose.

Effects and risk reduction

Effects and safer use

Common effects

Intense energy, wakefulness, focus, and reduced appetite; also sweating, jaw tension, anxiety, paranoia, and repetitive behaviour.

If you choose to use
  • Do not use alone
  • Avoid prolonged wakefulness and repeated dosing
  • Keep naloxone available if an illicit product may contain an opioid; naloxone does not reverse methamphetamine itself

Chemistry

Chemical structure

PubChem
2D structural formula: Methamphetamine. (2S)-N-methyl-1-phenylpropan-2-amine
MethamphetamineC10H15N
PubChem · CID 10836
Exact molecular identity

(2S)-N-methyl-1-phenylpropan-2-amine

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, emergency steps and sources

What the experience may feel like

Methamphetamine can cause intense energy, wakefulness, and concentration, but also jaw tension, sweating, a racing heart, anxiety, repetitive behaviour, and suspiciousness. It has a high addiction potential.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose information

No dose figure is published. The strength and contents of illicit products are unverified, and the same amount can have very different effects.

If the experience becomes an emergency

Emergency steps for Methamphetamine
  1. Stop further use and move the person to a calm, cool, and safe environment.
  2. Loosen tight clothing and cool them gently. Do not force a large amount of fluid at once, and do not give other substances in an attempt to balance the effects.
  3. Call 112 for chest pain, a seizure, a very high temperature, severe confusion, difficulty breathing, or sudden weakness on one side.
  4. Stay with the person, monitor their breathing, and follow the instructions from 112.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Chest pain, a seizure, a sudden headache, weakness on one side, or severe difficulty breathing.

Call 112

Main risks

What matters most

  • Heart attack or stroke
  • Seizures and overheating
  • Anxiety, paranoia, and compulsive redosing

Mixing

Combining with other substances

Alcohol and cocaine form a toxic breakdown product and increase strain on the heart. Also avoid other stimulants.

Effects and risk reduction

Effects and safer use

Common effects

Energy, alertness, increased confidence, and reduced appetite.

If you choose to use
  • Do not use alone
  • Take breaks and monitor your temperature and heartbeat
  • Do not share equipment that comes into contact with blood or mucous membranes

Chemistry

Chemical structure

PubChem
2D structural formula: Cocaine. methyl (1R,2R,3S,5S)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
CocaineC17H21NO4
PubChem · CID 446220
Exact molecular identity

methyl (1R,2R,3S,5S)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Effects often begin quickly and can include increased energy, confidence, talkativeness, and euphoria. The short effect and abrupt comedown can encourage redosing, while strain on the heart accumulates even as the euphoria fades.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table separates smoked, oral, intranasal, and intravenous use of verified cocaine. A serious cardiac or neurological event can occur at amounts below those shown in the table and without warning.

Cocaine by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 22 July 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. A serious cardiac or neurological event can occur at any amount. Purity, adulteration, and repeated dosing make the amounts particularly unreliable.

Cocaine

RouteSmoked

Threshold
2.5 mg
Light
5–15 mg
Common
15–30 mg
Strong
30–45 mg
Heavy
≥45 mg

Note: Very rapid onset encourages repeated dosing.

Cocaine

RouteOral

Threshold
13 mg
Light
13–75 mg
Common
75–150 mg
Strong
150–225 mg
Heavy
≥225 mg

Note: Effects may begin more slowly, but strain on the heart still accumulates.

Cocaine

RouteIntranasal

Threshold
5 mg
Light
10–30 mg
Common
30–60 mg
Strong
60–90 mg
Heavy
≥90 mg

Note: Repeated use damages the nasal lining and prolongs strain on the heart.

Cocaine

RouteIntravenous

Threshold
2 mg
Light
2–5 mg
Common
5–10 mg
Strong
10–15 mg
Heavy
≥15 mg

Note: Very rapid onset and a high risk of cardiac arrest, overdose, infection, and vein damage.

If the experience becomes an emergency

Emergency steps for Cocaine
  1. Stop further use and move the person to a calm, cool, and safe environment.
  2. Loosen tight clothing and cool them gently. Do not force a large amount of fluid at once, and do not give other substances in an attempt to balance the effects.
  3. Call 112 for chest pain, a seizure, a very high temperature, severe confusion, difficulty breathing, or sudden weakness on one side.
  4. Stay with the person, monitor their breathing, and follow the instructions from 112.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Chest pain, high temperature, a seizure, impaired consciousness, or uncontrollable agitation.

Call 112

Main risks

What matters most

  • Overheating and strain on the heart
  • Severe anxiety or psychosis
  • Compulsive redosing

Mixing

Combining with other substances

Other stimulants and some serotonergic medicines can increase strain on temperature regulation, the heart, and the nervous system. The risk depends on the substance actually present.

Effects and risk reduction

Effects and safer use

Common effects

Energy, euphoria, sociability, and increased heart rate.

If you choose to use
  • Assume the name and contents may be wrong
  • Do not use alone
  • Avoid staying awake for long periods and hot environments

Chemical structure

This name covers multiple molecules or unknown contents. A single structural formula cannot represent it; choose a specific substance to see its structure.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Effects can include energy, euphoria, sociability, and sexual arousal, but also a very rapid heartbeat, anxiety, and compulsive redosing. 3-MMC, 4-MMC, and other cathinones are not equivalent.

Duration by route

No single duration applies to this group or unknown contents. Choose a specific substance for route-specific information where available.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table applies only to verified 4-MMC, also called mephedrone, and separates oral from intranasal use. It does not apply to 3-MMC or to synthetic cathinones as a class.

4-MMC (mephedrone) by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 10 September 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. This table applies only to verified 4-MMC. It does not apply to 3-MMC, another cathinone, or a product sold only under a particular name.

4-MMC

RouteOral

Threshold
15 mg
Light
50–100 mg
Common
100–200 mg
Strong
200–300 mg
Heavy
≥300 mg

Note: The urge to redose, overheating, and strain on the heart can increase quickly.

4-MMC

RouteIntranasal

Threshold
5 mg
Light
15–45 mg
Common
45–80 mg
Strong
80–125 mg
Heavy
≥125 mg

Note: Faster onset and a strong urge to redose.

If the experience becomes an emergency

Emergency steps for Synthetic cathinones
  1. Stop further use and move the person to a calm, cool, and safe environment.
  2. Loosen tight clothing and cool them gently. Do not force a large amount of fluid at once, and do not give other substances in an attempt to balance the effects.
  3. Call 112 for chest pain, a seizure, a very high temperature, severe confusion, difficulty breathing, or sudden weakness on one side.
  4. Stay with the person, monitor their breathing, and follow the instructions from 112.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Severe nausea, sweating, confusion, difficulty breathing, a seizure, or impaired consciousness.

Call 112

Main risks

What matters most

  • Strong dependence
  • Heart and blood vessel damage, especially from tobacco
  • Nicotine poisoning in children and adults

Mixing

Combining with other substances

Other stimulants can worsen uncomfortable heartbeats and high blood pressure.

Effects and risk reduction

Effects and safer use

Common effects

Alertness, temporary calm, and increased heart rate.

If you choose to use
  • Keep liquids and pouches locked away from children and animals
  • Wash skin immediately if liquid spills onto it
  • Call the Poison Information Centre if ingestion is suspected

Chemistry

Chemical structure

PubChem
2D structural formula: Nicotine. 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
NicotineC10H14N2
PubChem · CID 89594
Exact molecular identity

3-[(2S)-1-methylpyrrolidin-2-yl]pyridine

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Nicotine can cause brief alertness, concentration, calm, or pleasure. Too much often becomes unpleasant quickly, with nausea, sweating, excess saliva, dizziness, tremor, and a racing heart.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table separates smoked, swallowed, and buccal nicotine according to the source. The amount shown on a pouch, liquid, or package is not necessarily equal to the absorbed dose.

Nicotine by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 22 July 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. The amounts refer to nicotine, not automatically to the amount printed on a pouch, liquid, or package. Absorption and the actual strength of products vary.

Nicotine

RouteSmoked

Threshold
0.2 mg
Light
0.3–0.8 mg
Common
0.8–1.5 mg
Strong
1.5–3.5 mg
Heavy
≥3.5 mg

Note: Does not automatically apply to e-cigarette liquid or the amount printed on packaging.

Nicotine

RouteOral (swallowed)

Threshold
0.2 mg
Light
1–3 mg
Common
3–5 mg
Strong
5–7 mg
Heavy
≥7 mg

Note: Swallowed nicotine can cause poisoning; do not induce vomiting.

Nicotine

RouteBuccal

Threshold
0.2 mg
Light
0.5–2 mg
Common
2–4 mg
Strong
4–6 mg
Heavy
≥6 mg

Note: Pouches may contain a different amount from the label, and absorption varies.

If the experience becomes an emergency

Emergency steps for Nicotine
  1. Remove nicotine pouches from the mouth and stop further use. Do not induce vomiting.
  2. If nicotine liquid has leaked onto the skin, wash it immediately with soap and water and remove contaminated clothing.
  3. Call the Landspítali Poison Information Centre on 543 2222 if ingestion or poisoning is suspected.
  4. Call 112 for difficulty breathing, a seizure, severe confusion, collapse, or impaired consciousness.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Chest pain, a seizure, fainting, difficulty breathing, symptoms of a stroke, or extreme agitation.

Call 112

Main risks

What matters most

  • Heart and blood pressure problems
  • Seizures and overheating
  • Anxiety, psychosis, and insomnia

Mixing

Combining with other substances

Other stimulants, cocaine, and MAO inhibitors can dangerously increase blood pressure, temperature, and strain on the heart.

Effects and risk reduction

Effects and safer use

Common effects

Alertness, focus, and reduced appetite. Euphoria, anxiety, and restlessness can also occur.

If you choose to use
  • Only take medicines from a pharmacy that were prescribed to you
  • Avoid extra doses and staying awake for long periods
  • Do not drive if you experience unusual or severe symptoms

Chemistry

Chemical structure

PubChem
2D structural formula: Methylphenidate. methyl 2-phenyl-2-piperidin-2-ylacetate
MethylphenidateC14H19NO2
PubChem · CID 4158
Exact molecular identity

methyl 2-phenyl-2-piperidin-2-ylacetate

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Methylphenidate can increase alertness and concentration but can also cause reduced appetite, a racing heart, anxiety, and restlessness. Misuse or prolonged wakefulness can lead to confusion and psychosis.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table separates oral and intranasal methylphenidate according to the source. Immediate-release and extended-release formulations are not interchangeable.

Methylphenidate by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 22 July 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. Immediate-release and extended-release formulations are not equivalent, and crushing an extended-release medicine can change absorption dangerously.

Methylphenidate

RouteOral

Threshold
5 mg
Light
10–20 mg
Common
20–40 mg
Strong
40–60 mg
Heavy
≥60 mg

Note: Take the medicine only as prescribed and in its prescribed formulation.

Methylphenidate

RouteIntranasal

Threshold
1 mg
Light
2–10 mg
Common
10–30 mg
Strong
30–60 mg
Heavy
≥60 mg

Note: A crushed tablet contains binders and can damage the nose; faster absorption increases strain on the heart.

If the experience becomes an emergency

Emergency steps for Methylphenidate
  1. Stop further use and move the person to a calm, cool, and safe environment.
  2. Loosen tight clothing and cool them gently. Do not force a large amount of fluid at once, and do not give other substances in an attempt to balance the effects.
  3. Call 112 for chest pain, a seizure, a very high temperature, severe confusion, difficulty breathing, or sudden weakness on one side.
  4. Stay with the person, monitor their breathing, and follow the instructions from 112.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Empathogens

1

Urgent warning

Call 112 if

Very high temperature, confusion, rigid muscles, a seizure, impaired consciousness, or a rapid irregular pulse.

Call 112

Main risks

What matters most

  • Overheating and salt imbalance
  • Serotonin syndrome
  • Anxiety, exhaustion, and low mood after use

Mixing

Combining with other substances

Avoid other stimulants and medicines that affect serotonin. Depressants can hide warning signs.

Effects and risk reduction

Effects and safer use

Common effects

Increased closeness, euphoria, energy, and sensitivity to touch and music.

If you choose to use
  • Take regular breaks from dancing and heat
  • Drink moderately and regularly. Do not drink litres at once
  • Do not use alone
  • Avoid redosing. It can cause the amount in your body to build up and increase heat and strain on the heart

Chemistry

Chemical structure

PubChem
2D structural formula: MDMA. 1-(1,3-benzodioxol-5-yl)-N-methylpropan-2-amine
MDMAC11H15NO2
PubChem · CID 1615
Exact molecular identity

1-(1,3-benzodioxol-5-yl)-N-methylpropan-2-amine

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Common effects include increased closeness, empathy, energy, euphoria, and sensitivity to music or touch. Larger doses increase jaw tension, confusion, overheating, and strain on the heart without necessarily improving the desired effects.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The guidelines apply only to verified oral MDMA. A tablet, colour, or crystals confirm neither contents nor amount, and repeated dosing can cause the concentration to accumulate before the earlier dose has peaked.

MDMA by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 22 July 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. A tablet, colour, or crystals confirm neither contents nor amount. Repeated dosing and serotonergic medicines can increase the risk of overheating and serotonin syndrome.

MDMA

RouteOral

Threshold
20 mg
Light
20–80 mg
Common
80–120 mg
Strong
120–150 mg
Heavy
≥150 mg

Note: Applies only to verified MDMA, not a tablet or powder of uncertain contents.

If the experience becomes an emergency

Emergency steps for MDMA
  1. Stop further use and move the person to a calm, cool, and safe environment.
  2. Loosen tight clothing and cool them gently. Do not force a large amount of fluid at once, and do not give other substances in an attempt to balance the effects.
  3. Call 112 for chest pain, a seizure, a very high temperature, severe confusion, difficulty breathing, or sudden weakness on one side.
  4. Stay with the person, monitor their breathing, and follow the instructions from 112.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Psychedelics

6

Urgent warning

Call 112 if

A person poses a danger to themselves or others, has a seizure, collapses, or shows persistent symptoms of psychosis.

Call 112

Main risks

What matters most

  • Panic and dangerous behaviour
  • Rare psychotic reactions; risk may be greater with an existing mental health condition
  • Accidents due to impaired perception of reality

Mixing

Combining with other substances

Combinations can make psychological effects and behaviour more unpredictable; especially avoid stimulants and cannabis if anxiety increases.

Effects and risk reduction

Effects and safer use

Common effects

Visual and emotional changes in perception, increased sensitivity, and unpredictable psychological effects.

If you choose to use
  • Choose calm, safe surroundings
  • Have a sober, trusted person nearby
  • Avoid use if you are mentally unstable or have a history of psychosis

Chemistry

Chemical structure

PubChem
2D structural formula: LSD. (6aR,9R)-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
LSDC20H25N3O
PubChem · CID 5761
Exact molecular identity

(6aR,9R)-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

LSD can intensify colours, patterns, connections between thoughts, emotions, and altered time perception. The experience is often stimulating and long-lasting; anxiety, thought loops, paranoia, and loss of the sense of self become more likely as the effect grows stronger.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table applies only to verified LSD used sublingually and measured in micrograms. The strength of blotter paper or drops is rarely verified, and NBOMe, NBOH, or other substances may be sold as LSD.

LSD by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 10 September 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. The strength of blotter paper or drops is rarely verified, and NBOMe, NBOH, or other substances may be sold as LSD.

LSD

RouteSublingual

Threshold
15 µg
Light
15–75 µg
Common
75–150 µg
Strong
150–300 µg
Heavy
≥300 µg

Note: Micrograms cannot be seen with the naked eye, and a label on blotter paper does not verify its strength.

If the experience becomes an emergency

Emergency steps for LSD
  1. Move the person to a calm, familiar environment and reduce light, noise, and the number of people present.
  2. Have one sober, trusted person stay with them. Speak calmly, use short sentences, and remind them that the effects will pass.
  3. Do not argue about delusions and do not restrain the person unless an immediate danger makes it necessary.
  4. Call 112 for a seizure, chest pain, impaired consciousness, suicide risk, uncontrollable dangerous behaviour, or persistent psychotic symptoms.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Severe vomiting, a seizure, impaired consciousness, difficulty breathing, or dangerous behaviour.

Call 112

Main risks

What matters most

  • Panic and confusion
  • Poisonous mushrooms due to misidentification
  • Psychosis-like symptoms or worsening mental health problems

Mixing

Combining with other substances

Combinations can increase anxiety, confusion, and physical risks.

Effects and risk reduction

Effects and safer use

Common effects

Altered perception, emotions, and thinking; sometimes nausea or anxiety.

If you choose to use
  • Never eat wild mushrooms that have not been positively identified
  • Choose calm surroundings and a trusted companion
  • Avoid use if you are mentally unstable

Chemistry

Chemical structure

PubChem

These diagrams show specific active compounds in the plant or mushrooms, not their full composition.

2D structural formula: Psilósýbín. [3-[2-(dimethylamino)ethyl]-1H-indol-4-yl] dihydrogen phosphate
PsilósýbínC12H17N2O4P
PubChem · CID 10624
Exact molecular identity

[3-[2-(dimethylamino)ethyl]-1H-indol-4-yl] dihydrogen phosphate

2D structural formula: Psilósín. 3-[2-(dimethylamino)ethyl]-1H-indol-4-ol
PsilósínC12H16N2O
PubChem · CID 4980
Exact molecular identity

3-[2-(dimethylamino)ethyl]-1H-indol-4-ol

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

The experience is often dreamlike, emotional, and introspective, with altered colours, patterns, and time perception. Nausea, yawning, bodily heaviness, confusion, and intense waves of emotion may occur.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table applies to pure oral psilocybin, not grams of mushrooms. Do not convert the ranges into mushroom weight because potency varies greatly and wild mushrooms can be misidentified.

Pure psilocybin by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 10 September 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. The amounts apply to pure psilocybin, not grams of mushrooms. Mushroom potency varies greatly, and wild mushrooms can be misidentified.

Psilocybin

RouteOral

Threshold
2.5 mg
Light
2.5–10 mg
Common
10–25 mg
Strong
25–50 mg
Heavy
≥50 mg

Note: Do not convert these amounts directly into a weight of mushrooms.

If the experience becomes an emergency

Emergency steps for Psilocybin
  1. Move the person to a calm, familiar environment and reduce light, noise, and the number of people present.
  2. Have one sober, trusted person stay with them. Speak calmly, use short sentences, and remind them that the effects will pass.
  3. Do not argue about delusions and do not restrain the person unless an immediate danger makes it necessary.
  4. Call 112 for a seizure, chest pain, impaired consciousness, suicide risk, uncontrollable dangerous behaviour, or persistent psychotic symptoms.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Chest pain, a seizure, high temperature, blue or cold limbs, or impaired consciousness.

Call 112

Main risks

What matters most

  • Anxiety, confusion, or panic
  • A rapid pulse or raised blood pressure
  • Nausea, headache, or muscle cramps

Mixing

Combining with other substances

Combinations with stimulants, MAO inhibitors, or other perception-altering substances can be especially unpredictable.

Effects and risk reduction

Effects and safer use

Common effects

Altered perception, energy, and hallucinations; effects depend heavily on the actual contents.

If you choose to use
  • Do not trust a name, colour, or logo as proof of contents
  • Do not use alone
  • Call for help early if wellbeing deteriorates quickly

Chemistry

Chemical structure

PubChem
2D structural formula: 2C-B and other new hallucinogens. 2-(4-bromo-2,5-dimethoxyphenyl)ethanamine
2C-B and other new hallucinogensC10H14BrNO2
PubChem · CID 98527
Exact molecular identity

2-(4-bromo-2,5-dimethoxyphenyl)ethanamine

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

2C-B can alter colours, patterns, touch, thought, and time perception, with stimulation. Nausea, headache, a racing heart, anxiety, confusion, or panic can also occur.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table separates four routes of administration for verified 2C-B. It does not apply at all to NBOMe, NBOH, DOB, or unknown powder sold under the same name.

Verified 2C-B by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 10 September 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. The amounts do not apply to NBOMe, NBOH, DOB, or other substances that may be sold under the same name and have a much narrower margin for error.

2C-B

RouteOral

Threshold
5 mg
Light
10–15 mg
Common
15–25 mg
Strong
25–45 mg
Heavy
≥45 mg

Note: Applies only to 2C-B with verified contents.

2C-B

RouteIntranasal

Threshold
<1 mg
Light
5–8 mg
Common
8–12 mg
Strong
12–23 mg
Heavy
≥23 mg

Note: Much faster and often more painful onset than oral use.

2C-B

RouteRectal

Threshold
<1 mg
Light
5–8 mg
Common
8–12 mg
Strong
12–23 mg
Heavy
≥23 mg

Note: Faster absorption than oral use; the amount does not apply to unknown powder.

2C-B

RouteIntravenous

Threshold
<1 mg
Light
1–2.5 mg
Common
2.5–5 mg
Strong
5–10 mg
Heavy
≥10 mg

Note: A very narrow margin for error and a high risk of overdose, infection, and vein damage.

If the experience becomes an emergency

Emergency steps for 2C-B and other new hallucinogens
  1. Move the person to a calm, familiar environment and reduce light, noise, and the number of people present.
  2. Have one sober, trusted person stay with them. Speak calmly, use short sentences, and remind them that the effects will pass.
  3. Do not argue about delusions and do not restrain the person unless an immediate danger makes it necessary.
  4. Call 112 for a seizure, chest pain, impaired consciousness, suicide risk, uncontrollable dangerous behaviour, or persistent psychotic symptoms.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

A seizure, chest pain, unconsciousness, difficulty breathing, dangerous behaviour, or persistent symptoms of psychosis.

Call 112

Main risks

What matters most

  • Panic and dangerous behaviour
  • Vomiting and aspiration
  • Dangerous interactions due to MAO inhibitors

Mixing

Combining with other substances

The MAO inhibitors in ayahuasca and changa can interact dangerously with many antidepressants, stimulants, and tramadol.

Effects and risk reduction

Effects and safer use

Common effects

Profound changes in vision and the perception of the body and time. Nausea, vomiting, fear, and confusion can occur.

If you choose to use
  • Choose calm, safe surroundings with a sober, trusted person
  • Clearly distinguish between DMT and a mixture containing an MAO inhibitor
  • Avoid use if you are at risk of psychosis

Chemistry

Chemical structure

PubChem
2D structural formula: DMT / ayahuasca. 2-(1H-indol-3-yl)-N,N-dimethylethanamine
DMT / ayahuascaC12H16N2
PubChem · CID 6089
Exact molecular identity

2-(1H-indol-3-yl)-N,N-dimethylethanamine

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

DMT can cause a very rapid and profound change in vision, time, the body, and the sense of self. Ayahuasca acts for longer and often causes nausea and vomiting because it has a different composition and is taken orally.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table separates smoked or vaporised DMT from intravenous DMT. It does not apply to ayahuasca, changa, or other mixtures containing MAO inhibitors.

DMT by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 22 July 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. The amounts apply only to verified N,N-DMT and do not apply to ayahuasca, changa, or other mixtures containing MAO inhibitors.

N,N-DMT

RouteSmoked / vaporised

Threshold
2 mg
Light
10–20 mg
Common
20–40 mg
Strong
40–60 mg
Heavy
≥60 mg

Note: Effects can become very intense within seconds; use a safe environment without fall or fire hazards.

N,N-DMT

RouteIntravenous

Threshold
4 mg
Light
4–10 mg
Common
10–15 mg
Strong
15–20 mg
Heavy
≥20 mg

Note: Very rapid onset and a high risk of overdose, infection, and vein damage.

If the experience becomes an emergency

Emergency steps for DMT / ayahuasca
  1. Move the person to a calm, familiar environment and reduce light, noise, and the number of people present.
  2. Have one sober, trusted person stay with them. Speak calmly, use short sentences, and remind them that the effects will pass.
  3. Do not argue about delusions and do not restrain the person unless an immediate danger makes it necessary.
  4. Call 112 for a seizure, chest pain, impaired consciousness, suicide risk, uncontrollable dangerous behaviour, or persistent psychotic symptoms.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Chest pain, a seizure, very high temperature, unconsciousness, dangerous behaviour, or persistent symptoms of psychosis.

Call 112

Main risks

What matters most

  • Panic and accidents
  • Prolonged physical strain and dehydration
  • A poisonous or misidentified plant or mixture

Mixing

Combining with other substances

Stimulants, cannabis, and other psychedelics can increase unpredictability and physical strain.

Effects and risk reduction

Effects and safer use

Common effects

Visual changes, altered emotions and sense of time, nausea, and increased heart rate.

If you choose to use
  • Expect a long duration and choose safe surroundings
  • Have a sober, trusted person nearby
  • Do not trust the appearance of a plant or product as proof of its contents

Chemistry

Chemical structure

PubChem
2D structural formula: Mescaline. 2-(3,4,5-trimethoxyphenyl)ethanamine
MescalineC11H17NO3
PubChem · CID 4076
Exact molecular identity

2-(3,4,5-trimethoxyphenyl)ethanamine

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Mescaline can cause colourful visual changes, altered perception of time and emotion, physical stimulation, and nausea. Its long duration can become difficult if anxiety or confusion develops.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table applies only to pure oral mescaline. It must not be converted directly into a weight of cacti or plants with variable and unverified potency.

Pure mescaline by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 22 July 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. The amounts apply to pure mescaline and must not be converted directly into a weight of peyote, San Pedro, or other cacti of variable potency.

Mescaline

RouteOral

Threshold
50 mg
Light
50–200 mg
Common
200–400 mg
Strong
400–800 mg
Heavy
≥800 mg

Note: Slow onset and long duration can encourage redosing before the peak is reached.

If the experience becomes an emergency

Emergency steps for Mescaline
  1. Move the person to a calm, familiar environment and reduce light, noise, and the number of people present.
  2. Have one sober, trusted person stay with them. Speak calmly, use short sentences, and remind them that the effects will pass.
  3. Do not argue about delusions and do not restrain the person unless an immediate danger makes it necessary.
  4. Call 112 for a seizure, chest pain, impaired consciousness, suicide risk, uncontrollable dangerous behaviour, or persistent psychotic symptoms.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Severe injury after a fall, a seizure, unconsciousness, difficulty breathing, or persistent symptoms.

Call 112

Main risks

What matters most

  • Falls and accidents
  • Panic and dangerous movements
  • Persistent anxiety or feelings of unreality

Mixing

Combining with other substances

Avoid other psychoactive substances because the effects can be unpredictable and extremely strong.

Effects and risk reduction

Effects and safer use

Common effects

Profound changes in the perception of the body and surroundings, dissociation, confusion, and brief but intense hallucinations.

If you choose to use
  • Stay seated or lying down, away from windows, water, traffic, and heights
  • Have a sober, trusted person nearby
  • Avoid fire and smoking when you are alone

Chemistry

Chemical structure

PubChem

These diagrams show specific active compounds in the plant or mushrooms, not their full composition.

2D structural formula: Salvinorín A. methyl (2S,4aR,6aR,7R,9S,10aS,10bR)-9-acetyloxy-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,8,9,10a-octahydro-1H-benzo[f]isochromene-7-carboxylate
Salvinorín AC23H28O8
PubChem · CID 128563
Exact molecular identity

methyl (2S,4aR,6aR,7R,9S,10aS,10bR)-9-acetyloxy-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,8,9,10a-octahydro-1H-benzo[f]isochromene-7-carboxylate

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, emergency steps and sources

What the experience may feel like

Salvia can abruptly disconnect a person from their body and surroundings. A feeling of being pulled, twisted, or transported elsewhere and uncontrolled movements can occur.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose information

No dose amount is published. The potency of leaves and extracts varies greatly, and product labelling is not reliable confirmation of the contents.

If the experience becomes an emergency

Emergency steps for Salvia divinorum
  1. Move the person to a calm, familiar environment and reduce light, noise, and the number of people present.
  2. Have one sober, trusted person stay with them. Speak calmly, use short sentences, and remind them that the effects will pass.
  3. Do not argue about delusions and do not restrain the person unless an immediate danger makes it necessary.
  4. Call 112 for a seizure, chest pain, impaired consciousness, suicide risk, uncontrollable dangerous behaviour, or persistent psychotic symptoms.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Dissociatives

4

Urgent warning

Call 112 if

A person is unresponsive, breathing abnormally, vomiting while their consciousness is impaired, or having a seizure.

Call 112

Main risks

What matters most

  • Falls, choking, and accidents
  • Impaired consciousness
  • Bladder and urinary tract damage with frequent use

Mixing

Combining with other substances

Alcohol, opioids, benzodiazepines, and GHB/GBL increase the risk of unconsciousness and breathing problems.

Effects and risk reduction

Effects and safer use

Common effects

Numbness, altered perception, relaxation, and dissociation.

If you choose to use
  • Stay seated or lying down, away from water, traffic, and heights
  • Do not use alone
  • Seek medical advice for pain or blood in your urine

Chemistry

Chemical structure

PubChem
2D structural formula: Ketamine. 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one
KetamineC13H16ClNO
PubChem · CID 3821
Exact molecular identity

2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

At lower amounts, ketamine can cause numbness, relaxation, unsteadiness, and detachment from the body. Higher amounts can disrupt connection with the surroundings, memory, movement, and speech and lead to a profound dissociative experience.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table separates oral and intranasal ketamine. It does not apply to esketamine medicines, other routes, mixtures, or powder of unknown purity.

Ketamine by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 22 July 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. The amounts apply only to verified ketamine. They do not apply to esketamine medicines, mixtures, or powder of unknown purity.

Ketamine

RouteOral

Threshold
50 mg
Light
50–100 mg
Common
100–300 mg
Strong
300–450 mg
Heavy
≥450 mg

Note: Later onset can encourage dangerous repeated dosing.

Ketamine

RouteIntranasal

Threshold
5 mg
Light
10–30 mg
Common
30–75 mg
Strong
75–150 mg
Heavy
≥150 mg

Note: Dissociation and impaired movement increase the risk of falls, choking, and vomiting.

If the experience becomes an emergency

Emergency steps for Ketamine
  1. Stop all further use and do not give food, drink, or any other substances.
  2. Check responsiveness and breathing. Call 112 if the person is difficult to wake, is breathing abnormally, vomits while their consciousness is impaired, or has a seizure.
  3. If the person is breathing normally, place them in the recovery position and monitor their breathing continuously.
  4. Give naloxone only when opioid use is suspected. Naloxone does not reverse alcohol, GHB, or benzodiazepines on their own.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Difficulty breathing, blue discolouration, unconsciousness, weakness, or new numbness in the limbs.

Call 112

Main risks

What matters most

  • Oxygen deprivation and unconsciousness
  • Cold burns from pressurised cylinders
  • B12-related nerve and spinal cord damage

Mixing

Combining with other substances

Depressants increase the risk of oxygen deprivation, falls, and unconsciousness.

Effects and risk reduction

Effects and safer use

Common effects

Brief euphoria, laughter, dizziness, and altered perception.

If you choose to use
  • Never inhale directly from a cylinder or charger
  • Do not use in an enclosed space or with a bag over your head
  • Seek medical advice for numbness, weakness, or difficulty walking

Chemistry

Chemical structure

PubChem
2D structural formula: Nitrous oxide. nitrous oxide
Nitrous oxideN2O
PubChem · CID 948
Exact molecular identity

nitrous oxide

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Nitrous oxide causes very brief euphoria, buzzing, dizziness, altered sound, and dissociation from the body or surroundings. Repeated inhalation can cause oxygen deprivation without a clear sense of danger.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: PsychonautWiki classifies inhaled gas by grams, but the amount says nothing about oxygen supply, equipment, or the speed of repetition. It is therefore not a safety limit.

Nitrous oxide by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 22 July 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. The number of grams says nothing about oxygen supply, equipment, or the speed of repetition. Never inhale directly from a pressurised cylinder or from a sealed mask or bag.

Nitrous oxide

RouteInhaled

Threshold
4 g
Light
4–8 g
Common
8–16 g
Strong
16–40 g
Heavy
≥40 g

Note: The source equates these ranges to about ½–1, 1–2, 2–5, and more than 5 small cartridges, but cartridge sizes are not standardised.

If the experience becomes an emergency

Emergency steps for Nitrous oxide
  1. Stop inhalation and move the person into fresh air without putting yourself at risk.
  2. Call 112 for blue skin or lips, difficulty breathing, a seizure, unconsciousness, or if the person does not recover quickly.
  3. If the person is breathing normally, place them in the recovery position and monitor their breathing. Give CPR as directed by 112 if breathing is not normal.
  4. Seek medical help promptly for new numbness, weakness, balance problems, or difficulty walking after repeated use because of the risk of B12-related nerve damage.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Difficulty breathing, a seizure, very high temperature, severe confusion, repeated vomiting, or no response.

Call 112

Main risks

What matters most

  • Poisoning from other ingredients
  • Serotonin syndrome and seizures
  • Accidents, vomiting, and unconsciousness

Mixing

Combining with other substances

Serotonergic medicines, MAO inhibitors, tramadol, and MDMA can cause serotonin syndrome. Alcohol and depressants increase the risk of unconsciousness.

Effects and risk reduction

Effects and safer use

Common effects

Dissociation, euphoria, slurred speech, impaired coordination, hallucinations, and nausea.

If you choose to use
  • Always check all active ingredients in the product
  • Never use a combination medicine to become intoxicated
  • Do not drive or use alone

Chemistry

Chemical structure

PubChem
2D structural formula: DXM. (1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene
DXMC18H25NO
PubChem · CID 5360696
Exact molecular identity

(1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

DXM can cause numbness, unsteadiness, slurred speech, dissociation, and hallucinations. Combination cough products can also cause poisoning that is not due to DXM itself.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table applies only to oral dextromethorphan on its own. Combination cough and cold products may contain paracetamol, antihistamines, or other medicines that become life-threatening at much lower amounts.

Pure DXM by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 22 July 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. The amounts apply only to dextromethorphan on its own. Many cough products also contain paracetamol, antihistamines, or other medicines that can cause life-threatening poisoning.

DXM

RouteOral

Threshold
75 mg
Light
100–200 mg
Common
200–400 mg
Strong
400–700 mg
Heavy
≥700 mg

Note: Check every active ingredient; combination cough medicines can become dangerous long before the DXM range is reached.

If the experience becomes an emergency

Emergency steps for DXM
  1. Stop further use and move the person away from traffic, water, heights, and other hazards.
  2. Speak calmly and use short sentences. Do not restrain the person unless an immediate danger makes it necessary.
  3. Call 112 for difficulty breathing, a seizure, chest pain, a very high temperature, impaired consciousness, or uncontrollable dangerous behaviour.
  4. Monitor breathing and place the person in the recovery position if they are breathing normally but are unresponsive.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Dangerous agitation, chest pain, a seizure, very high temperature, unconsciousness, or abnormal breathing.

Call 112

Main risks

What matters most

  • Severe agitation, psychosis, and accidents
  • High blood pressure, high temperature, and seizures
  • Coma and impaired breathing

Mixing

Combining with other substances

Alcohol, benzodiazepines, and opioids increase the risk of unconsciousness and breathing problems. Stimulants increase temperature, strain on the heart, and agitation.

Effects and risk reduction

Effects and safer use

Common effects

Dissociation, numbness, hallucinations, and impaired coordination and speech.

If you choose to use
  • Avoid unknown powders and liquids
  • Stay in a calm, safe place with a sober companion
  • Do not restrain a person unless there is immediate danger, and call 112

Chemistry

Chemical structure

PubChem
2D structural formula: PCP. 1-(1-phenylcyclohexyl)piperidine
PCPC17H25N
PubChem · CID 6468
Exact molecular identity

1-(1-phenylcyclohexyl)piperidine

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

PCP can cause numbness, dissociation, severe confusion, hallucinations, and impaired coordination. Behaviour and physical symptoms can change quickly and become unpredictable.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table separates smoked, oral, and intranasal PCP. Mislabelled products, unknown potency, and mixtures can make every amount meaningless.

PCP by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 22 July 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. Products sold as PCP can vary in potency, be mislabelled, or be mixed. The source specifically associates “Heavy” with psychosis and mania.

PCP

RouteSmoked

Threshold
1 mg
Light
2–4 mg
Common
4–8 mg
Strong
8–12 mg
Heavy
≥12 mg

Note: A fast-acting route; confusion and dangerous behaviour can occur suddenly.

PCP

RouteOral

Threshold
1 mg
Light
3–5 mg
Common
5–10 mg
Strong
10–15 mg
Heavy
≥15 mg

Note: Later onset can encourage repeated dosing.

PCP

RouteIntranasal

Threshold
1 mg
Light
2–4 mg
Common
4–8 mg
Strong
8–15 mg
Heavy
≥15 mg

Note: Unknown powder makes the amounts unusable.

If the experience becomes an emergency

Emergency steps for PCP
  1. Stop further use and move the person away from traffic, water, heights, and other hazards.
  2. Speak calmly and use short sentences. Do not restrain the person unless an immediate danger makes it necessary.
  3. Call 112 for difficulty breathing, a seizure, chest pain, a very high temperature, impaired consciousness, or uncontrollable dangerous behaviour.
  4. Monitor breathing and place the person in the recovery position if they are breathing normally but are unresponsive.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Cannabis products

2

Urgent warning

Call 112 if

Chest pain, a seizure, unconsciousness, extreme agitation, or symptoms of psychosis.

Call 112

Main risks

What matters most

  • Panic attacks or paranoia
  • Impaired driving and accidents
  • Acute psychotic symptoms; risk may be greater in vulnerable people

Mixing

Combining with other substances

Alcohol and other substances can increase dizziness, nausea, anxiety, and impaired judgement.

Effects and risk reduction

Effects and safer use

Common effects

Relaxation, altered perception, and increased appetite; sometimes anxiety, confusion, or panic.

If you choose to use
  • Avoid driving and operating machinery
  • Choose calm surroundings and people you trust
  • The effects of edibles may be delayed and last longer than expected

Chemistry

Chemical structure

PubChem

These diagrams show specific active compounds in the plant or mushrooms, not their full composition.

2D structural formula: Δ⁹-THC. (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-ol
Δ⁹-THCC21H30O2
PubChem · CID 16078
Exact molecular identity

(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-ol

2D structural formula: CBD. 2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol
CBDC21H30O2
PubChem · CID 644019
Exact molecular identity

2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol

Reference structures from PubChem. Salts and stereoisomers may differ; a diagram does not verify a product’s contents or purity. Select an image to enlarge it.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

The experience can include relaxation, laughter, heightened perception, altered time perception, and increased appetite. Larger amounts can cause severe dizziness, a racing heart, confusion, a sense of unreality, anxiety, or paranoia.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: The table separates the amount of THC smoked from the amount taken orally. It does not apply to the weight of flower, hash, homemade edibles, or a product with unverified contents.

THC by route of administration

All five levels are user-reported guidelines from PsychonautWiki as retrieved on 10 September 2026. They are not medical dosing advice. “Heavy” is a high-risk category, not a recommendation, and routes of administration are not interchangeable. The amounts refer to THC, not the weight of flower, hash, homemade edibles, or concentrates. Product labels and actual THC content can differ greatly.

THC

RouteSmoked

Threshold
0.4 mg
Light
0.4–2 mg
Common
2–4 mg
Strong
4–10 mg
Heavy
≥10 mg

Note: Does not apply to grams of cannabis flower or an unlabelled product.

THC

RouteOral

Threshold
1 mg
Light
2.5–5 mg
Common
5–10 mg
Strong
10–25 mg
Heavy
≥25 mg

Note: Effects begin later and last longer; redosing before effects appear increases risk.

If the experience becomes an emergency

Emergency steps for Cannabis
  1. Stop further use and move to a calm, cool, familiar environment with a trusted sober person.
  2. Remind the person that the effects of THC will pass. Reduce noise and stimulation, and avoid driving or walking near traffic, water, or heights.
  3. Call 112 for chest pain, a seizure, unconsciousness, difficulty breathing, uncontrollable dangerous behaviour, or severe psychotic symptoms.
  4. Seek health advice if vomiting is repeated, anxiety does not subside, or mental symptoms continue after the intoxication should have passed.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Seizures, high temperature, chest pain, extreme aggression, unconsciousness, or difficulty breathing.

Call 112

Main risks

What matters most

  • Seizures and psychosis
  • Abnormal heart rhythms
  • Kidney damage and unconsciousness

Mixing

Combining with other substances

Interactions are poorly studied and unpredictable. Especially avoid other stimulants or psychoactive substances.

Effects and risk reduction

Effects and safer use

Common effects

Effects may resemble cannabis, but severe agitation, confusion, and physical symptoms are more common.

If you choose to use
  • The safest option is to avoid substances with unknown contents
  • Do not use alone
  • Call for help early if behaviour or wellbeing changes quickly

Chemical structure

This name covers multiple molecules or unknown contents. A single structural formula cannot represent it; choose a specific substance to see its structure.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

The effects can resemble THC but are often much more intense and unpredictable. Severe agitation, confusion, hallucinations, vomiting, seizures, and sudden impairment of consciousness can occur without a clear gradual warning.

Duration by route

No single duration applies to this group or unknown contents. Choose a specific substance for route-specific information where available.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: There is no usable low, moderate, or high dose amount. Different cannabinoids vary enormously in potency, and the substance may be distributed unevenly through a liquid or herbal mixture.

Low according to the source

Cannot be calculated
Mild perceptual changes can suddenly progress to anxiety, a rapid pulse, or confusion.

Moderate according to the source

Cannot be calculated
Severe agitation, vomiting, paranoia, unsteadiness, and difficulty communicating.

High according to the source

Cannot be calculated
Seizures, high temperature, unconsciousness, abnormal heart rhythm, or difficulty breathing. This is an emergency.

If the experience becomes an emergency

Emergency steps for Synthetic cannabinoids
  1. Stop use and move the person away from traffic, water, heights, and objects that could cause injury.
  2. Reduce noise and the number of people present. Do not provoke or restrain the person unless an immediate danger makes it necessary.
  3. Call 112 early if the person deteriorates rapidly or has severe agitation, a seizure, chest pain, a high temperature, impaired consciousness, or difficulty breathing.
  4. Stay with the person and tell the emergency operator that a synthetic cannabinoid or unknown liquid may be involved.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Inhalants

2

Urgent warning

Call 112 if

Collapse, an irregular heartbeat, difficulty breathing, a seizure, or unconsciousness.

Call 112

Main risks

What matters most

  • Sudden cardiac arrest
  • Oxygen deprivation and suffocation
  • Burns, poisoning, and nerve damage

Mixing

Combining with other substances

Other depressants increase the risk of suffocation and unconsciousness; stimulants can increase strain on the heart.

Effects and risk reduction

Effects and safer use

Common effects

Short-lived intoxication, dizziness, confusion, and drowsiness.

If you choose to use
  • The safest option is not to inhale these substances
  • Move into fresh air without putting yourself at risk
  • Call 112 for any severe symptoms

Chemical structure

This name covers multiple molecules or unknown contents. A single structural formula cannot represent it; choose a specific substance to see its structure.

More information

Experience, timeline, dose references, emergency steps and sources

What the experience may feel like

Vapours can cause sudden dizziness, drowsiness, confusion, unsteadiness, and brief euphoria. An abnormal heart rhythm, oxygen deprivation, or sudden collapse can occur even after one use.

Duration by route

No single duration applies to this group or unknown contents. Choose a specific substance for route-specific information where available.

Source: PsychonautWiki · Data retrieved

Dose ranges are not safety limits

These community-reported reference ranges come from PsychonautWiki and, where stated, TripSit. They are not necessarily pharmacologically or medically validated, do not identify a safe dose and are not a recommendation to use.

“Heavy” means a very large, high-risk amount, not a target. Serious harm, hospital admission or death can occur at much lower amounts. Strength, contents, route, tolerance, health, medicines and mixing can change the effects.

The cards reproduce every level shown by the named source. If a product contains an unknown or mislabelled substance, every dose figure may be irrelevant.

For this substance: A low or safe dose cannot be calculated for butane, petrol, glue, aerosols, or solvents. Concentration, ventilation, temperature, and chemical composition change the risk.

Low according to the source

Cannot be calculated
Dizziness, headache, nausea, confusion, and impaired coordination can already indicate poisoning.

Moderate according to the source

Cannot be calculated
Severe drowsiness, slurred speech, vomiting, unsteadiness, and breathing discomfort.

High according to the source

Cannot be calculated
Collapse, a seizure, abnormal heart rhythm, respiratory arrest, burns, or unconsciousness. This is an emergency.

If the experience becomes an emergency

Emergency steps for Volatile inhalants
  1. Move the person into fresh air only if it is safe. Do not enter a vapour-contaminated space without appropriate protection.
  2. Call 112 for difficulty breathing, collapse, a seizure, an abnormal heart rhythm, or impaired consciousness.
  3. Avoid flames, sparks, cigarettes, and electrical switches near flammable vapours.
  4. If the person is breathing normally, place them in the recovery position and monitor their breathing until help arrives.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Urgent warning

Call 112 if

Blue or grey skin and lips, difficulty breathing, chest pain, fainting, a seizure, or severe confusion.

Call 112

Main risks

What matters most

  • Severe drop in blood pressure and fainting
  • Methaemoglobinaemia and oxygen deprivation
  • Chemical burns and eye damage

Mixing

Combining with other substances

Never combine with sildenafil, tadalafil, vardenafil, or nitrate medicines because of the risk of a life-threatening drop in blood pressure.

Effects and risk reduction

Effects and safer use

Common effects

A brief feeling of warmth, dizziness, pressure in the head, muscle relaxation, and a rapid heartbeat.

If you choose to use
  • Never swallow the liquid or put it on your skin or in your eyes
  • Keep the substance away from fire, children, and animals
  • Seek immediate help for breathing or vision symptoms

Chemical structure

This name covers multiple molecules or unknown contents. A single structural formula cannot represent it; choose a specific substance to see its structure.

More information

Experience, timeline, emergency steps and sources

What the experience may feel like

Alkyl nitrites cause rapid widening of blood vessels, with warmth, dizziness, a faster pulse, and brief muscle relaxation. Blood pressure can fall enough to make a person faint.

Duration by route

Onset is the time until the first effects. Total duration describes the main effects; after-effects are listed separately and may last longer.

These are estimated ranges from a community source, not medical safety limits. Amount, formulation, tolerance, combinations and individual differences affect timing. These ranges do not establish when it is safe to take more or drive. Not specified means the retrieved data has no figure, not that the time is zero.

Source: PsychonautWiki · Data retrieved

Dose information

No dose amount is published. Products may contain different alkyl nitrites, and the liquid is not intended to be swallowed or to come into contact with skin or eyes.

If the experience becomes an emergency

Emergency steps for Poppers / alkyl nitrites
  1. Stop use and move the person into fresh air if it is safe.
  2. Call 112 for blue or grey lips, difficulty breathing, chest pain, fainting, a seizure, or impaired consciousness.
  3. If the liquid has spilled on the skin or into the eyes, rinse immediately with plenty of water and seek medical help.
  4. Do not induce vomiting if the liquid has been swallowed. Keep the packaging available for responders.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Other or unknown

1

Urgent warning

Call 112 if

Difficulty breathing, impaired consciousness, a seizure, chest pain, very high temperature, blue discolouration, or uncontrollable behaviour.

Call 112

Main risks

What matters most

  • Unknown strength and contents
  • Unexpected and dangerous combinations
  • Delayed or recurring severe symptoms

Mixing

Combining with other substances

Interaction risks cannot be assessed when the contents are unknown. Do not add other substances in an attempt to balance the effects.

Effects and risk reduction

Effects and safer use

Common effects

Effects may be stimulating, depressant, perception-altering, or a mixture of several types, and can change rapidly.

If you choose to use
  • The safest option is not to use the substance
  • Do not trust colour, markings, or a seller as confirmation of contents
  • Do not use alone, and keep packaging or a sample for responders if an emergency occurs

Chemical structure

This name covers multiple molecules or unknown contents. A single structural formula cannot represent it; choose a specific substance to see its structure.

More information

Experience, timeline, emergency steps and sources

What the experience may feel like

An unknown substance can have depressant, stimulant, psychedelic, or dissociative effects, and more than one mechanism of action. A name, colour, logo, or package does not predict the actual experience.

Duration by route

No single duration applies to this group or unknown contents. Choose a specific substance for route-specific information where available.

Source: PsychonautWiki · Data retrieved

Dose information

No dose amount is published. When the contents and strength are unknown, an amount cannot responsibly be classified as low, moderate, or high.

If the experience becomes an emergency

Emergency steps for Unknown or mislabelled substances
  1. Stop further use and do not give other substances in an attempt to balance the effects.
  2. Call 112 for difficulty breathing, impaired consciousness, a seizure, chest pain, a very high temperature, blue skin or lips, or uncontrollable behaviour.
  3. Give naloxone when opioid use is suspected and follow the instructions from 112.
  4. Keep any packaging or sample for responders if this can be done without risk.
Call 112
Sources and limitations

PsychonautWiki and TripSit are community sources, not official medical guidance. Official emergency advice always takes priority when someone may be in danger. Where relevant, community information is compared with official health sources.

.

Live estimate · worldwide

Estimated direct drug-related deaths so far this year

Ekki tiltækt

About 473 a dayAbout one death every 3 minutes

UNODC estimates about 173,000 direct drug-related deaths in 2023, mainly overdose deaths and mostly involving opioids. This counter spreads that annual estimate evenly across the year; it is not a real-time registry of confirmed deaths.

View the UNODC data